DUSP5 Antibody (E-4): sc-515667
- DUSP5 Antibody (E-4) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 362-383 at the C-terminus of DUSP5 of human origin
- recommended for detection of DUSP5 of human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for DUSP5 Antibody (E-4) for WB applications. This reagent is now offered in a bundle with DUSP5 Antibody (E-4) (see ordering information below).
DUSP5 Antibody (E-4) is a mouse monoclonal IgG3 antibody that detects DUSP5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DUSP5 is a crucial member of the dual specificity phosphatase family, known for dephosphorylating both phosphothreonine and phosphotyrosine residues, particularly within MAP kinases. This function plays a significant role in regulating cellular signaling pathways that control cell growth, differentiation, and response to stress. DUSP5 is predominantly located in the nucleus, where DUSP5 exerts regulatory effects on MAPK signaling, particularly influencing ERK1 activity. Nuclear localization allows for precise modulation of signaling pathways critical for cellular responses to external stimuli, thereby maintaining cellular homeostasis. Anti-DUSP5 antibody (E-4) serves as an invaluable tool for researchers studying MAP kinase regulation mechanisms and implications in various physiological and pathological processes.
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DUSP5 Antibody (E-4) References:
- Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. | Holmes, DA., et al. 2015. EMBO J. 34: 218-35. PMID: 25398911
- DUSP5 expression associates with poor prognosis in human neuroblastoma. | Aurtenetxe, O., et al. 2018. Exp Mol Pathol. 105: 272-278. PMID: 30171833
- Endoplasmic Reticulum Stress Increases DUSP5 Expression via PERK-CHOP Pathway, Leading to Hepatocyte Death. | Jo, HJ., et al. 2019. Int J Mol Sci. 20: PMID: 31491992
- DUSP5 (dual-specificity protein phosphatase 5) suppresses BCG-induced autophagy via ERK 1/2 signaling pathway. | Luo, J., et al. 2020. Mol Immunol. 126: 101-109. PMID: 32795663
- DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. | Ferguson, BS., et al. 2021. Am J Physiol Heart Circ Physiol. 321: H382-H389. PMID: 34142888
- miR-203 suppresses pancreatic cancer cell proliferation and migration by modulating DUSP5 expression. | Altan, Z. and Sahin, Y. 2022. Mol Cell Probes. 66: 101866. PMID: 36183924
- The Role of Epinephelus coioides DUSP5 in Regulating Singapore Grouper Iridovirus Infection. | He, J., et al. 2023. Viruses. 15: PMID: 37766214
- Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib. | Chen, P., et al. 2024. Endocrine. 85: 1268-1277. PMID: 38564084
- Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation. | Song, G., et al. 2024. J Nanobiotechnology. 22: 236. PMID: 38724995
- ASAH1 facilitates TNBC by DUSP5 suppression-driven activation of MAP kinase pathway and represents a therapeutic vulnerability. | Reddi, KK., et al. 2024. Cell Death Dis. 15: 452. PMID: 38926346
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DUSP5 Antibody (E-4) | sc-515667 | 200 µg/ml | $322.00 | |||
DUSP5 Antibody (E-4): m-IgG3 BP-HRP Bundle | sc-550538 | 200 µg Ab; 40 µg BP | $361.00 |