DPPA2 Antibody (210CT5.14.6.1): sc-517326
- DPPA2 Antibody (210CT5.14.6.1) is a mouse monoclonal IgG1 κ DPPA2 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to DPPA2 of human origin
- recommended for detection of DPPA2 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DPPA2 Antibody (210CT5.14.6.1). This work is in progress.
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DPPA2 Antibody (210CT5.14.6.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects human DPPA2 by western blotting (WB). Anti-DPPA2 antibody (210CT5.14.6.1) is available as a non-conjugated format. DPPA2, also known as developmental pluripotency associated 2 or PESCRG1 (pluripotent embryonic stem cell-related gene 1 protein), consists of 298 amino acids and is primarily localized in the nucleus, where DPPA2 plays a crucial role in maintaining pluripotency in embryonic stem cells. DPPA2 helps regulate the balance between self-renewal and differentiation, which is essential for proper development and tissue homeostasis. Dysregulation of DPPA2 has been implicated in abnormal cell growth and cancer formation, highlighting DPPA2′s importance in tumor biology. The gene encoding DPPA2 is located on human chromosome 3, a region that harbors over 1,100 genes, including several key tumor suppressor genes such as RASSF1, which mediates apoptosis, and SEMA3B, which is involved in angiogenesis suppression. Additionally, chromosome 3 is associated with various genetic disorders, including Marfan Syndrome and von Hippel-Lindau syndrome, underscoring DPPA2′s significance in both developmental processes and disease states.
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DPPA2 Antibody (210CT5.14.6.1) References:
- Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. | Bortvin, A., et al. 2003. Development. 130: 1673-80. PMID: 12620990
- [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification]. | Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
- Plasticity of human chromosome 3 during primate evolution. | Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
- Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution. | Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
- Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'. | Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
- Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line. | Maldonado-Saldivia, J., et al. 2007. Stem Cells. 25: 19-28. PMID: 16990585
- Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. | Ruau, D., et al. 2008. Stem Cells. 26: 920-6. PMID: 18203677
- Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development. | Monk, M., et al. 2008. Mol Hum Reprod. 14: 347-55. PMID: 18467432
- ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. | John, T., et al. 2008. Clin Cancer Res. 14: 3291-8. PMID: 18519755
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DPPA2 Antibody (210CT5.14.6.1) | sc-517326 | 100 µg/ml | $322.00 |