DnaJB4 Antibody (R-07): sc-100711

DnaJB4 Antibody (R-07) is a mouse monoclonal IgG1 kappa light chain antibody that detects DnaJB4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-DnaJB4 antibody (R-07) is available as a non-conjugated format. The DnaJ family, to which DnaJB4 belongs, is one of the largest chaperone families and is characterized by diverse cellular localization and functions, primarily defined by the presence of the J domain. DnaJB4 plays a crucial role in cellular stress response, particularly in the regulation of protein folding and degradation, which is vital for maintaining cellular homeostasis. DnaJB4 is predominantly expressed in skeletal muscle, heart, and pancreas, with lower levels found in brain, placenta, and liver. DnaJB4 interacts with HSP 70, a key player in the heat shock protein family, to facilitate ATP hydrolysis, thereby enhancing the chaperone′s ability to assist in protein folding and prevent aggregation. The presence of cysteine-rich regions and zinc finger motifs within DnaJB4 contributes to peptide binding capabilities, underscoring importance in proteostasis. anti-DnaJB4 antibody (R-07) enables valuable insights into mechanisms of protein homeostasis and cellular response to stress, making this product an essential tool for studies related to muscle and cardiac function, as well as various metabolic processes.

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DnaJB4 Antibody (R-07) References:

1. Analysis of the function of mycobacterial DnaJ proteins by overexpression and microarray profiling.  |  Stewart, GR., et al. 2004. Tuberculosis (Edinb). 84: 180-7. PMID: 15207487
2. The C-terminal (331-376) sequence of Escherichia coli DnaJ is essential for dimerization and chaperone activity: a small angle X-ray scattering study in solution.  |  Shi, YY., et al. 2005. J Biol Chem. 280: 22761-8. PMID: 15849180
3. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones.  |  Qiu, XB., et al. 2006. Cell Mol Life Sci. 63: 2560-70. PMID: 16952052
4. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions.  |  Genevaux, P., et al. 2007. Mol Microbiol. 66: 840-57. PMID: 17919282
5. DnaJ recruits DnaK to protein aggregates.  |  Acebrón, SP., et al. 2008. J Biol Chem. 283: 1381-1390. PMID: 17984091
6. Organization and expression of the dnaJ and dnaK genes of Escherichia coli K12.  |  Saito, H. and Uchida, H. 1978. Mol Gen Genet. 164: 1-8. PMID: 360036
7. Identification of the E. coli dnaJ gene product.  |  Georgopoulos, CP., et al. 1980. Mol Gen Genet. 178: 583-8. PMID: 6446654
8. Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli.  |  Tomoyasu, T., et al. 1998. Mol Microbiol. 30: 567-81. PMID: 9822822
9. Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.  |  Suh, WC., et al. 1998. Proc Natl Acad Sci U S A. 95: 15223-8. PMID: 9860950

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DnaJB4 Antibody (R-07) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-DnaJB4 Antibody (R-07) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DnaJB4 Antibody (R-07) Specifications

Alternate Product Name: DnaJB4

Product Clone Name: R-07

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-338

Epitope Target: DnaJB4

Epitope Species: human

Product Reactivity/Detection: DnaJB4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for DnaJB4 Antibody (R-07): N/A