DMGDH Antibody (A-9): sc-398256

DMGDH Antibody (A-9) is a mouse monoclonal IgG2a light chain antibody that detects dimethylglycine dehydrogenase (DMGDH) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DMGDH is an 866 amino acid mitochondrial protein that plays a crucial role in choline catabolism by catalyzing the demethylation of dimethylglycine to form sarcosine, a process vital for maintaining proper metabolic function. DMGDH exists as a monomer and belongs to the gcvT family, utilizing flavin adenine dinucleotide (FAD) and folate as essential cofactors for activity. DMGDH gene is located on human chromosome 5q14.1, and mutations can lead to DMGDH deficiency, a condition characterized by muscle fatigue, a distinctive fish-like odor, and elevated levels of N,N-dimethylglycine in urine. DMGDH′s interaction with other metabolic pathways highlights DMGDH′s importance in cellular metabolism and energy production, making anti-DMGDH antibody (A-9) an invaluable tool for researchers studying metabolic disorders and mitochondrial function.

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DMGDH Antibody (A-9) References:

1. Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study.  |  Moolenaar, SH., et al. 1999. Clin Chem. 45: 459-64. PMID: 10102904
2. Expression of acidosis-dependent genes in human cancer nests.  |  Fukamachi, T., et al. 2014. Mol Clin Oncol. 2: 1160-1166. PMID: 25279216
3. Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.  |  Demirkan, A., et al. 2015. PLoS Genet. 11: e1004835. PMID: 25569235
4. Molecular characterization of paediatric glioneuronal tumours with neuropil-like islands: a genome-wide copy number analysis.  |  Giunti, L., et al. 2016. Am J Cancer Res. 6: 2910-2918. PMID: 28042510
5. Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.  |  Wang, P., et al. 2018. Oral Dis. 24: 820-828. PMID: 29356306
6. Identification of coordinately regulated microRNA-gene networks that differ in baboons discordant for LDL-cholesterol.  |  Karere, GM., et al. 2019. PLoS One. 14: e0213494. PMID: 30875406
7. Identification of glutamyl-prolyl-tRNA synthetase as a new therapeutic target in hepatocellular carcinoma via a novel bioinformatic approach.  |  Shu, J., et al. 2023. J Gastrointest Oncol. 14: 636-649. PMID: 37201074
8. Elucidation of population stratifying markers and selective sweeps in crossbred Landlly pig population using genome-wide SNP data.  |  Saini, T., et al. 2024. Mamm Genome. 35: 170-185. PMID: 38485788
9. Genomic regions and biological mechanisms underlying climatic resilience traits derived from automatically-recorded vaginal temperature in lactating sows under heat stress conditions.  |  Wen, H., et al. 2024. Front Genet. 15: 1498380. PMID: 39574795
10. Folate-binding proteins of liver mitochondria: dimethylglycine dehydrogenase and sarcosine dehydrogenase.  |  . 1981. Nutr Rev. 39: 408-10. PMID: 6171757

The preferred DMGDH antibody is DMGDH Antibody (E-6): sc-393178.