DMBT1 Antibody (H-4): sc-514887
- DMBT1 Antibody (H-4) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 25-48 near the N-terminus of DMBT1 of mouse origin
- recommended for detection of DMBT1a, DMBT1b and DMBT1c of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DMBT1 Antibody (H-4). This work is in progress.
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DMBT1 Antibody (H-4) is a mouse monoclonal IgM antibody that detects DMBT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DMBT1, or Deleted in Malignant Brain Tumors 1, plays a crucial role in tumor suppression and is involved in various cellular processes, including cell adhesion and signaling. DMBT1 expression is particularly significant in cancer, as reduced levels of DMBT1 mRNA have been associated with gastrointestinal, esophageal, and glioma malignancies, highlighting DMBT1′s potential as a biomarker for tumor progression. DMBT1 is primarily located in the extracellular matrix and interacts with several other proteins, including receptors and adhesion molecules, which are essential for maintaining tissue integrity and regulating cellular communication. DMBT1′s ability to modulate these interactions underscores DMBT1′s importance in preventing tumorigenesis and maintaining normal cellular functions. With broad species reactivity and versatile applications, anti-DMBT1 antibody (H-4) serves as an invaluable tool for researchers investigating molecular mechanisms underlying cancer and other diseases.
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DMBT1 Antibody (H-4) References:
- DMBT1 expression and glycosylation during the adenoma-carcinoma sequence in colorectal cancer. | Robbe, C., et al. 2005. Biochem Soc Trans. 33: 730-2. PMID: 16042587
- Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells. | Müller, H., et al. 2015. BMC Pulm Med. 15: 32. PMID: 25885541
- Elevated DMBT1 levels in neonatal gastrointestinal diseases. | Müller, H., et al. 2016. Histochem Cell Biol. 145: 227-37. PMID: 26542257
- DMBT1 promotes basal and meconium-induced nitric oxide production in human lung epithelial cells in vitro. | Müller, H., et al. 2017. Histochem Cell Biol. 147: 389-397. PMID: 27628193
- DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data. | Goeppert, B., et al. 2017. Histopathology. 70: 1064-1071. PMID: 28130841
- Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery. | Tuttolomondo, M., et al. 2017. Mol Ther Nucleic Acids. 8: 264-276. PMID: 28918028
- Silenced DMBT1 promotes nasal mucosa epithelial cell growth. | Lu, X., et al. 2018. Ann Hum Genet. 82: 102-108. PMID: 29148567
- DMBT1 is upregulated in lung epithelial cells after hypoxia and changes surfactant ultrastructure. | Müller, H., et al. 2020. Pediatr Pulmonol. 55: 2964-2969. PMID: 32770804
- Significance of DMBT1 in Papillary Thyroid Carcinoma Concurrent With Hashimoto's Thyroiditis. | Gan, XX., et al. 2021. Front Oncol. 11: 680873. PMID: 34422633
- DMBT1 expression and neutrophil-to-lymphocyte ratio during necrotizing enterocolitis are influenced by impaired perfusion due to cardiac anomalies. | Diez, S., et al. 2022. Mol Cell Pediatr. 9: 1. PMID: 34989914
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMBT1 Antibody (H-4) | sc-514887 | 200 µg/ml | $322.00 | |||
DMBT1 (H-4) Neutralizing Peptide | sc-514887 P | 100 µg/0.5 ml | $69.00 |