DMBT1 Antibody (G-4): sc-514566
- DMBT1 Antibody (G-4) is a mouse monoclonal IgG2b κ DMBT1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 25-49 near the N-terminus of DMBT1 of mouse origin
- DMBT1 Antibody (G-4) is recommended for detection of DMBT1a, DMBT1b and DMBT1c of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DMBT1 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DMBT1 Antibody (G-4) for WB applications. These reagents are now offered in bundles with DMBT1 Antibody (G-4) (see ordering information below).
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DMBT1 Antibody (G-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects DMBT1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DMBT1 (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DMBT1 protein plays a crucial role in regulating cell adhesion and migration, essential processes in tissue development and repair. DMBT1′s function as a tumor suppressor is particularly significant, as reduced levels of DMBT1 mRNA have been associated with various cancers, including gastrointestinal, esophageal, and gliomas. Loss of DMBT1 expression can lead to increased tumor aggressiveness and metastasis, highlighting DMBT1′s importance in cancer biology. Additionally, DMBT1 protein is involved in modulating immune response, further underscoring DMBT1′s relevance in both tumor suppression and immune regulation. Understanding DMBT1′s dynamics and interactions with other proteins can provide valuable insights into therapeutic strategies for cancer treatment and development of targeted therapies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DMBT1 Antibody (G-4) References:
- Silencing of DMBT1 in neuroblastoma cell lines is not due to methylation of CCWGG motifs on its promoter. | Muñoz, J. and Castresana, JS. 2006. Neoplasma. 53: 15-8. PMID: 16416007
- Single nucleotide polymorphisms in the DMBT1 promoter and the progression of breast cancer. | Lei, H., et al. 2007. Int J Cancer. 120: 447-9. PMID: 17066405
- Clonal genomic alterations in glioma malignancy stages. | James, CD., et al. 1988. Cancer Res. 48: 5546-51. PMID: 2901288
- Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis. | Chen, CY., et al. 2018. Theranostics. 8: 1607-1623. PMID: 29556344
- DMBT1 involvement in the human aortic endothelial cell response to Streptococcus mutans. | Oho, T. and Nagata, E. 2019. Mol Oral Microbiol. 34: 108-117. PMID: 30861638
- Specific chromosomal abnormalities in malignant human gliomas. | Bigner, SH., et al. 1988. Cancer Res. 48: 405-11. PMID: 3335011
- DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine. | Kiefer, A., et al. 2022. Mol Cell Pediatr. 9: 4. PMID: 35249163
- PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. | Li, J., et al. 1997. Science. 275: 1943-7. PMID: 9072974
- Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. | Steck, PA., et al. 1997. Nat Genet. 15: 356-62. PMID: 9090379
- DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. | Mollenhauer, J., et al. 1997. Nat Genet. 17: 32-9. PMID: 9288095
- A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. | Chernova, OB., et al. 1998. Oncogene. 17: 2873-81. PMID: 9879993
- Lack of DMBT1 expression in oesophageal, gastric and colon cancers. | Mori, M., et al. 1999. Br J Cancer. 79: 211-3. PMID: 9888459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMBT1 Antibody (G-4) | sc-514566 | 200 µg/ml | $322.00 | |||
DMBT1 Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-531161 | 200 µg Ab; 10 µg BP | $361.00 | |||
DMBT1 Antibody (G-4): m-IgGκ BP-HRP Bundle | sc-524771 | 200 µg Ab, 40 µg BP | $361.00 | |||
DMBT1 Antibody (G-4): m-IgG2b BP-HRP Bundle | sc-550262 | 200 µg Ab; 10 µg BP | $361.00 | |||
DMBT1 Antibody (G-4) AC | sc-514566 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DMBT1 Antibody (G-4) HRP | sc-514566 HRP | 200 µg/ml | $322.00 | |||
DMBT1 Antibody (G-4) FITC | sc-514566 FITC | 200 µg/ml | $336.00 | |||
DMBT1 Antibody (G-4) PE | sc-514566 PE | 200 µg/ml | $349.00 | |||
DMBT1 Antibody (G-4) Alexa Fluor® 488 | sc-514566 AF488 | 200 µg/ml | $364.00 | |||
DMBT1 Antibody (G-4) Alexa Fluor® 546 | sc-514566 AF546 | 200 µg/ml | $364.00 | |||
DMBT1 Antibody (G-4) Alexa Fluor® 594 | sc-514566 AF594 | 200 µg/ml | $364.00 | |||
DMBT1 Antibody (G-4) Alexa Fluor® 647 | sc-514566 AF647 | 200 µg/ml | $364.00 | |||
DMBT1 Antibody (G-4) Alexa Fluor® 680 | sc-514566 AF680 | 200 µg/ml | $364.00 | |||
DMBT1 Antibody (G-4) Alexa Fluor® 790 | sc-514566 AF790 | 200 µg/ml | $364.00 | |||
DMBT1 (G-4) Neutralizing Peptide | sc-514566 P | 100 µg/0.5 ml | $69.00 |