DMBT1 Antibody (A-2): sc-514888
- DMBT1 Antibody (A-2) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 25-48 near the N-terminus of DMBT1 of mouse origin
- recommended for detection of DMBT1a, DMBT1b and DMBT1c of mouse origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DMBT1 Antibody (A-2). This work is in progress.
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SEE ALSO...
DMBT1 Antibody (A-2) is a mouse monoclonal IgM antibody that detects DMBT1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DMBT1, or Deleted in Malignant Brain Tumors 1, plays a crucial role in tumor suppression and is involved in various cellular processes, including cell adhesion and signaling. DMBT1 expression is particularly significant in neural tissues, where DMBT1 interacts with several transmembrane and extracellular proteins that function as receptors and adhesion molecules, thereby influencing cellular communication and stability. Loss of DMBT1 expression has been associated with the progression of gastrointestinal and esophageal cancers, as well as gliomas, highlighting DMBT1′s importance as a potential biomarker and therapeutic target in cancer research. Anti-DMBT1 antibody (A-2) provides a valuable tool for researchers investigating DMBT1′s role in tumor biology and potential implications in cancer diagnostics and treatment strategies.
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DMBT1 Antibody (A-2) References:
- DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. | Mollenhauer, J., et al. 2000. Cancer Res. 60: 1704-10. PMID: 10749143
- Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis. | Mollenhauer, J., et al. 2004. Genes Chromosomes Cancer. 39: 185-94. PMID: 14732920
- DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. | Renner, M., et al. 2007. Gastroenterology. 133: 1499-509. PMID: 17983803
- DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. | End, C., et al. 2009. Eur J Immunol. 39: 833-42. PMID: 19189310
- Copy number variation of scavenger-receptor cysteine-rich domains within DMBT1 and Crohn's disease. | Polley, S., et al. 2016. Eur J Hum Genet. 24: 1294-300. PMID: 26813944
- Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway. | Shen, S., et al. 2016. Oncotarget. 7: 72833-72844. PMID: 27637083
- DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway by targeting PTEN. | Sheng, S., et al. 2019. Biosci Biotechnol Biochem. 83: 2257-2264. PMID: 31411121
- DMBT1 has a protective effect on allergic rhinitis. | Zhao, Y., et al. 2020. Biomed Pharmacother. 121: 109675. PMID: 31810134
- DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine. | Kiefer, A., et al. 2022. Mol Cell Pediatr. 9: 4. PMID: 35249163
- DMBT1 Alleviates Nasal Airway Inflammatory Response in the LPS-Induced Nasal Polyp Model. | Lu, X., et al. 2023. Int Arch Allergy Immunol. 184: 808-813. PMID: 37232026
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMBT1 Antibody (A-2) | sc-514888 | 200 µg/ml | $322.00 | |||
DMBT1 (A-2) Neutralizing Peptide | sc-514888 P | 100 µg/0.5 ml | $69.00 |