Dmap1 Antibody (B-10): sc-373949
- Dmap1 Antibody (B-10) is a mouse monoclonal IgG1 κ Dmap1 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Dmap1 of human origin
- Dmap1 Antibody (B-10) is recommended for detection of Dmap1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Dmap1 Antibody (B-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-373949 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dmap1 Antibody (B-10) for WB applications. These reagents are now offered in bundles with Dmap1 Antibody (B-10) (see ordering information below).
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SEE ALSO...
Dmap1 Antibody (B-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dmap1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dmap1 (B-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dmap1 protein plays a crucial role in regulating gene transcription through interaction with methylated DNA, specifically binding to methyl-CpG rich domains. This interaction mediates transcriptional repression associated with DNA methylation, a key epigenetic modification that influences gene expression in eukaryotic cells. Methylation predominantly occurs on cytosine residues within CpG dinucleotides and is facilitated by DNA methyltransferases, which are essential for maintaining cellular identity and regulating developmental processes. Additionally, Dmap1 interacts with Daxx, enhancing Daxx-mediated repression of glucocorticoid receptor transcriptional activity, while also being protected from degradation by Daxx in vivo. This multifaceted role of Dmap1 underscores its importance in epigenetic regulation and cellular function, making anti-Dmap1 antibody (B-10) a valuable tool for researchers studying gene expression and epigenetic modifications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dmap1 Antibody (B-10) References:
- Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells. | Xin, H., et al. 2004. J Biol Chem. 279: 9539-46. PMID: 14665632
- RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity. | Liu, Z. and Fisher, RA. 2004. J Biol Chem. 279: 14120-8. PMID: 14734556
- Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1. | Muromoto, R., et al. 2004. J Immunol. 172: 2985-93. PMID: 14978102
- Physical and functional interactions between Daxx and TSG101. | Muromoto, R., et al. 2004. Biochem Biophys Res Commun. 316: 827-33. PMID: 15033475
- Subcellular localization of RPB5-mediating protein and its putative functional partner. | Delgermaa, L., et al. 2004. Mol Cell Biol. 24: 8556-66. PMID: 15367675
- DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. | Boyes, J. and Bird, A. 1991. Cell. 64: 1123-34. PMID: 2004419
- Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. | Nan, X., et al. 1998. Nature. 393: 386-9. PMID: 9620804
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dmap1 Antibody (B-10) | sc-373949 | 200 µg/ml | $316.00 | |||
Dmap1 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-529617 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dmap1 Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-522565 | 200 µg Ab, 40 µg BP | $354.00 | |||
Dmap1 Antibody (B-10): m-IgG1 BP-HRP Bundle | sc-543608 | 200 µg Ab; 20 µg BP | $354.00 | |||
Dmap1 Antibody (B-10) X | sc-373949 X | 200 µg/0.1 ml | $316.00 | |||
Dmap1 Antibody (B-10) AC | sc-373949 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Dmap1 Antibody (B-10) HRP | sc-373949 HRP | 200 µg/ml | $316.00 | |||
Dmap1 Antibody (B-10) FITC | sc-373949 FITC | 200 µg/ml | $330.00 | |||
Dmap1 Antibody (B-10) PE | sc-373949 PE | 200 µg/ml | $343.00 | |||
Dmap1 Antibody (B-10) Alexa Fluor® 488 | sc-373949 AF488 | 200 µg/ml | $357.00 | |||
Dmap1 Antibody (B-10) Alexa Fluor® 546 | sc-373949 AF546 | 200 µg/ml | $357.00 | |||
Dmap1 Antibody (B-10) Alexa Fluor® 594 | sc-373949 AF594 | 200 µg/ml | $357.00 | |||
Dmap1 Antibody (B-10) Alexa Fluor® 647 | sc-373949 AF647 | 200 µg/ml | $357.00 | |||
Dmap1 Antibody (B-10) Alexa Fluor® 680 | sc-373949 AF680 | 200 µg/ml | $357.00 | |||
Dmap1 Antibody (B-10) Alexa Fluor® 790 | sc-373949 AF790 | 200 µg/ml | $357.00 |