DICE1 Antibody (H-6): sc-376524
- DICE1 Antibody (H-6) is a mouse monoclonal IgG1 κ DICE1 antibody, cited in 9 publications, provided at 200 µg/ml
- raised against amino acids 713-826 mapping near the C-terminus of DICE1 of human origin
- DICE1 Antibody (H-6) is recommended for detection of DICE1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DICE1 Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DICE1 Antibody (H-6) for WB applications. These reagents are now offered in bundles with DICE1 Antibody (H-6) (see ordering information below).
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SEE ALSO...
DICE1 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects DICE1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DICE1 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DICE1, also known as deleted in cancer 1, is located on chromosome 13q14 and is recognized as a tumor suppressor gene, particularly in non-small cell lung carcinoma. DICE1 expression is frequently lost or downregulated in these cancers compared to normal lung tissue, primarily due to loss of heterozygosity of chromosome 13, which is susceptible to deletions and rearrangements in lung cancer. DICE1 is homologous to mouse protein DBI-1 at the carboxy terminus, and high levels of DBI-1 can disrupt the mitogenic response to insulin-like growth factor 1 (IGF-1). Both DICE1 and DBI-1 share a highly conserved DEAD-box motif, indicating involvement in essential cellular functions and regulatory mechanisms. Understanding DICE1′s role in tumor suppression is crucial, as this knowledge may provide insights into potential therapeutic targets for treating non-small cell lung carcinoma and other malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DICE1 Antibody (H-6) References:
- How many tumor suppressor genes are involved in human lung carcinogenesis? | Kohno, T. and Yokota, J. 1999. Carcinogenesis. 20: 1403-10. PMID: 10426784
- Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas. | Wieland, I., et al. 1999. Oncogene. 18: 4530-7. PMID: 10467397
- Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt. | Irion, U. and Leptin, M. 1999. Curr Biol. 9: 1373-81. PMID: 10607561
- Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia. | Martín-Oliva, D., et al. 2004. Oncogene. 23: 5275-83. PMID: 15077172
- PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. | Hagberg, H., et al. 2004. J Neurochem. 90: 1068-75. PMID: 15312162
- Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer. | Hensel, CH., et al. 1990. Cancer Res. 50: 3067-72. PMID: 2159370
- DBI-1, a novel gene related to the notch family, modulates mitogenic response to insulin-like growth factor 1. | Hoff, HB., et al. 1998. Exp Cell Res. 238: 359-70. PMID: 9473344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DICE1 Antibody (H-6) | sc-376524 | 200 µg/ml | $316.00 | |||
DICE1 Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-529894 | 200 µg Ab; 10 µg BP | $354.00 | |||
DICE1 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-522990 | 200 µg Ab, 40 µg BP | $354.00 | |||
DICE1 Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-543751 | 200 µg Ab; 20 µg BP | $354.00 | |||
DICE1 Antibody (H-6) AC | sc-376524 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DICE1 Antibody (H-6) HRP | sc-376524 HRP | 200 µg/ml | $316.00 | |||
DICE1 Antibody (H-6) FITC | sc-376524 FITC | 200 µg/ml | $330.00 | |||
DICE1 Antibody (H-6) PE | sc-376524 PE | 200 µg/ml | $343.00 | |||
DICE1 Antibody (H-6) Alexa Fluor® 488 | sc-376524 AF488 | 200 µg/ml | $357.00 | |||
DICE1 Antibody (H-6) Alexa Fluor® 546 | sc-376524 AF546 | 200 µg/ml | $357.00 | |||
DICE1 Antibody (H-6) Alexa Fluor® 594 | sc-376524 AF594 | 200 µg/ml | $357.00 | |||
DICE1 Antibody (H-6) Alexa Fluor® 647 | sc-376524 AF647 | 200 µg/ml | $357.00 | |||
DICE1 Antibody (H-6) Alexa Fluor® 680 | sc-376524 AF680 | 200 µg/ml | $357.00 | |||
DICE1 Antibody (H-6) Alexa Fluor® 790 | sc-376524 AF790 | 200 µg/ml | $357.00 |