Dhh Antibody (D-4): sc-515757
- Dhh Antibody (D-4) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 29-51 at the N-terminus of Dhh of mouse origin
- recommended for detection of the N-terminal subunit of Dhh of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dhh Antibody (D-4) for WB applications. These reagents are now offered in bundles with Dhh Antibody (D-4) (see ordering information below).
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Dhh Antibody (D-4) is a mouse monoclonal IgG2b antibody that detects Desert hedgehog (Dhh) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dhh plays a crucial role in embryonic development and tissue patterning, functioning as a secreted signaling molecule that mediates cell-cell interactions. Dhh is particularly important in the development of the central nervous system and limb structures, where Dhh influences the growth and differentiation of various cell types. Dhh is synthesized as a precursor that undergoes post-translational modifications, including autocleavage, to produce an amino-terminal peptide that remains associated with the cell surface and a carboxy-terminal glycosylated peptide that is more diffusible. This processing is vital for signaling activity, as Dhh can interact with specific receptors on neighboring cells, thereby orchestrating complex developmental processes. Anti-Dhh antibody (D-4) is an essential tool for researchers studying the mechanisms of development and the roles of hedgehog signaling in various biological contexts.
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Dhh Antibody (D-4) References:
- Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons. | Liu, B., et al. Neurosci Lett. 384: 44-7. PMID: 15899548
- Hedgehog signaling pathway and gastric cancer. | Katoh, Y. and Katoh, M. 2005. Cancer Biol Ther. 4: 1050-4. PMID: 16258256
- Role of RecJ-like protein with 5'-3' exonuclease activity in oligo(deoxy)nucleotide degradation. | Wakamatsu, T., et al. 2011. J Biol Chem. 286: 2807-16. PMID: 21087930
- DHH is an independent prognosticator of oncologic outcome of clear cell renal cell carcinoma. | Jäger, W., et al. 2014. J Urol. 192: 1842-8. PMID: 25046620
- Testis Cord Maintenance in Mouse Embryos: Genes and Signaling. | Chen, SR. and Liu, YX. 2016. Biol Reprod. 94: 42. PMID: 26792939
- Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins. | Römling, U., et al. 2017. J Bacteriol. 199: PMID: 28031279
- Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats. | Takizawa, N., et al. 2018. Sci Rep. 8: 14542. PMID: 30266964
- In vitro functional characterization of the novel DHH mutations p.(Asn337Lysfs*24) and p.(Glu212Lys) associated with gonadal dysgenesis. | Tajouri, A., et al. 2018. Hum Mutat. 39: 2097-2109. PMID: 30298535
- Mutations in the desert hedgehog (DHH) gene in the disorders of sexual differentiation and male infertility. | Mehta, P., et al. 2021. J Assist Reprod Genet. 38: 1871-1878. PMID: 33712994
- Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling. | Sun, Y., et al. 2022. Theranostics. 12: 7307-7318. PMID: 36438492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dhh Antibody (D-4) | sc-515757 | 200 µg/ml | $322.00 | |||
Dhh Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-536498 | 200 µg Ab; 40 µg BP | $361.00 | |||
Dhh Antibody (D-4): m-IgG2b BP-HRP Bundle | sc-549546 | 200 µg Ab; 10 µg BP | $361.00 |