Dhh Antibody (D-4): sc-515757

Dhh Antibody (D-4) is a mouse monoclonal IgG2b antibody that detects Desert hedgehog (Dhh) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dhh plays a crucial role in embryonic development and tissue patterning, functioning as a secreted signaling molecule that mediates cell-cell interactions. Dhh is particularly important in the development of the central nervous system and limb structures, where Dhh influences the growth and differentiation of various cell types. Dhh is synthesized as a precursor that undergoes post-translational modifications, including autocleavage, to produce an amino-terminal peptide that remains associated with the cell surface and a carboxy-terminal glycosylated peptide that is more diffusible. This processing is vital for signaling activity, as Dhh can interact with specific receptors on neighboring cells, thereby orchestrating complex developmental processes. Anti-Dhh antibody (D-4) is an essential tool for researchers studying the mechanisms of development and the roles of hedgehog signaling in various biological contexts.

The preferred Dhh antibody is Dhh Antibody (F-9): sc-271168.