Dhh Antibody (A-12): sc-133244
- Dhh Antibody (A-12) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 227-311 of Dhh of human origin
- recommended for detection of Dhh of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dhh Antibody (A-12) for WB applications. These reagents are now offered in bundles with Dhh Antibody (A-12) (see ordering information below).
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Dhh Antibody (A-12) is a mouse monoclonal IgG2a antibody that detects Dhh in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dhh, or Desert hedgehog, plays a crucial role in embryonic development and tissue patterning by mediating cell-cell interactions, particularly in the development of the nervous system and limbs. Dhh is secreted and functions as a signaling molecule, influencing the behavior of neighboring cells during critical stages of development. Desert hedgehog (Dhh) regulates various cellular processes, including proliferation, differentiation, and survival, which are essential for proper organ formation and function. Additionally, Desert hedgehog interacts with specific receptors, such as Patched and Smoothened, which are integral to the Hedgehog signaling pathway, further underscoring its significance in developmental biology and potential implications in cancer research. Anti-Dhh antibody (A-12) is an invaluable tool for researchers studying these complex biological processes and the underlying mechanisms of diseases associated with Hedgehog signaling dysregulation.
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Dhh Antibody (A-12) References:
- Role of DHH superfamily proteins in nucleic acids metabolism and stress tolerance in prokaryotes and eukaryotes. | Srivastav, R., et al. 2019. Int J Biol Macromol. 127: 66-75. PMID: 30578903
- Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. | Shin, KO., et al. 2020. Cells. 9: PMID: 32164386
- Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration. | Ha, DH., et al. 2020. Cells. 9: PMID: 32392899
- DHH pathogenic variants involved in 46,XY disorders of sex development differentially impact protein self-cleavage and structural conformation. | Elzaiat, M., et al. 2020. Hum Genet. 139: 1455-1470. PMID: 32504121
- T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10. | Ravi, VM., et al. 2022. Nat Commun. 13: 925. PMID: 35177622
- Dhh signaling pathway regulates reconstruction of seminiferous tubule-like structure. | Min, M., et al. 2022. Reprod Biol. 22: 100684. PMID: 35987158
- Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness. | González-Mayoral, A., et al. 2023. J Endocrinol. 258: PMID: 37195271
- Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids. | Deng, L., et al. 2023. Neuron. 111: 2642-2659.e13. PMID: 37352856
- Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration. | Norris, AM., et al. 2023. Nat Commun. 14: 3766. PMID: 37355632
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dhh Antibody (A-12) | sc-133244 | 200 µg/ml | $322.00 | |||
Dhh Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-537362 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dhh Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-534608 | 200 µg Ab; 40 µg BP | $361.00 | |||
Dhh Antibody (A-12): m-IgG2a BP-HRP Bundle | sc-547990 | 200 µg Ab; 10 µg BP | $361.00 |