dHAND Antibody (HAND2C1a): sc-130629
- dHAND Antibody (HAND2C1a) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of dHAND of human origin
- recommended for detection of dHAND of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for dHAND Antibody (HAND2C1a). This work is in progress.
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dHAND Antibody (HAND2C1a) is a mouse monoclonal IgG1 antibody that detects dHAND in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). dHAND, a member of the basic-helix-loop-helix transcription factor family, plays a crucial role in cardiac development, particularly in establishing left-right asymmetry in the heart. dHAND is predominantly expressed on the right side of the looped heart tube and in the pulmonary ventricle, where dHAND activates the transcription of essential genes, including Ufd1, which is involved in the ubiquitin-proteasome pathway, and Cdc45, a key player in DNA replication. Proper functioning of dHAND is vital for the development of the heart′s structure, as dHAND influences the formation of specific heart chambers during cardiogenesis. Additionally, dHAND is expressed in sympathetic neurons and chromaffin cells throughout embryonic and fetal development, highlighting dHAND′s importance in neural crest development. Anti-dHAND antibody (HAND2C1a) specifically targets dHAND, making this antibody an invaluable tool for researchers studying cardiac development and related disorders.
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dHAND Antibody (HAND2C1a) References:
- The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. | Yamagishi, H., et al. 2000. J Clin Invest. 105: 261-70. PMID: 10675351
- The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. | Howard, MJ., et al. 2000. Development. 127: 4073-81. PMID: 10952904
- Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. | Charité, J., et al. 2001. Genes Dev. 15: 3039-49. PMID: 11711438
- Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. | Abe, M., et al. 2002. Cell Tissue Res. 310: 201-12. PMID: 12397375
- Cardiac phenotypes in chromosome 4q- syndrome with and without a deletion of the dHAND gene. | Huang, T., et al. 2002. Genet Med. 4: 464-7. PMID: 12509719
- dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. | Ruest, LB., et al. 2003. Dev Biol. 257: 263-77. PMID: 12729557
- Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity. | Murakami, M., et al. 2004. Eur J Biochem. 271: 3330-9. PMID: 15291810
- Cooperative activation of atrial naturetic peptide promoter by dHAND and MEF2C. | Zang, MX., et al. 2004. J Cell Biochem. 93: 1255-66. PMID: 15486975
- Regulation of dHAND protein expression by all-trans retinoic acid through ET-1/ETAR signaling in H9c2 cells. | Li, W. and Li, Y. 2006. J Cell Biochem. 99: 478-84. PMID: 16619265
- Generating dHAND homozygous knockout human embryonic stem cell line (WAe009-A-59) by episomal vector-based CRISPR/Cas9 system. | Wang, W., et al. 2021. Stem Cell Res. 55: 102471. PMID: 34332328
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
dHAND Antibody (HAND2C1a) | sc-130629 | 100 µg/ml | $339.00 |