DGUOK Antibody (G-2): sc-376256

DGUOK Antibody (G-2) is a mouse monoclonal IgG2b antibody that detects DGUOK in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). DGUOK, or deoxyguanosine kinase, is a crucial 277 amino acid protein primarily located in the mitochondria, where DGUOK plays a vital role in the phosphorylation of purine deoxyribonucleosides. This process is essential for maintaining mitochondrial DNA integrity, as DGUOK facilitates the conversion of deoxyguanosine to dGMP using ATP as a substrate. Proper functioning of DGUOK is particularly important because defects in DGUOK gene can lead to hepatocerebral mitochondrial DNA depletion syndrome, a serious condition characterized by a significant reduction in mitochondrial DNA copy number, resulting in severe liver failure and neurological abnormalities. Anti-DGUOK antibody (G-2) shows high expression across various tissues, including the liver, muscle, and brain, making anti-DGUOK antibody (G-2) an invaluable tool for researchers studying mitochondrial function and related disorders.

The preferred DGUOK antibody is DGUOK Antibody (H-3): sc-376267.