DGAT2 Antibody (4C1): sc-293211

DGAT2 Antibody (4C1) is a mouse monoclonal IgG2a kappa light chain antibody that detects DGAT2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DGAT2 antibody (4C1) is available as a non-conjugated format. DGAT2 plays a crucial role in lipid metabolism, specifically in triglyceride synthesis, which is essential for energy storage in the body. Unlike DGAT1, DGAT2 is primarily expressed in liver and white adipose tissue, indicating significant involvement in mammalian triglyceride metabolism. DGAT2 catalyzes the final step in converting diacylglycerol and fatty acyl-CoA into triglycerides, a process vital for maintaining energy homeostasis. DGAT2′s activity is uniquely regulated by magnesium chloride, which can inhibit function in vitro, highlighting the importance of post-translational modifications in regulatory mechanisms. Understanding DGAT2′s role in lipid metabolism is essential, as dysregulation of triglyceride synthesis can lead to metabolic disorders such as obesity and diabetes.

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DGAT2 Antibody (4C1) References:

1. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.  |  Cases, S., et al. 2001. J Biol Chem. 276: 38870-6. PMID: 11481335
2. Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content.  |  Winter, A., et al. 2002. Proc Natl Acad Sci U S A. 99: 9300-5. PMID: 12077321
3. Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin.  |  Meegalla, RL., et al. 2002. Biochem Biophys Res Commun. 298: 317-23. PMID: 12413942
4. ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.  |  Calle, RA., et al. 2021. Nat Med. 27: 1836-1848. PMID: 34635855
5. An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis.  |  Yenilmez, B., et al. 2022. Mol Ther. 30: 1329-1342. PMID: 34774753
6. Benzimidazolone Derivatives as DGAT2 Inhibitors for Treating Diseases.  |  Sabnis, RW. 2022. ACS Med Chem Lett. 13: 1004-1005. PMID: 35928852
7. The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7.  |  Chen, W., et al. 2024. Cardiovasc Diabetol. 23: 21. PMID: 38195542
8. DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER.  |  Rong, S., et al. 2024. Cell Metab. 36: 617-629.e7. PMID: 38340721
9. The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.  |  Deng, B., et al. 2024. J Transl Med. 22: 290. PMID: 38500157
10. DGAT2 Plays a Crucial Role to Control ESRRA-PROX1 Transcriptional Network to Maintain Hepatic Mitochondrial Sustainability.  |  Lee, Y., et al. 2024. Diabetes Metab J. 48: 901-914. PMID: 38644620
11. Rab1b facilitates lipid droplet growth by ER-to-lipid droplet targeting of DGAT2.  |  Malis, Y., et al. 2024. Sci Adv. 10: eade7753. PMID: 38809969
12. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.  |  Cases, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 13018-23. PMID: 9789033

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DGAT2 Antibody (4C1) has 19 citations in a variety of scientific publications.

Primary antibodies like Anti-DGAT2 Antibody (4C1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DGAT2 Antibody (4C1) Specifications

Alternate Product Name: DGAT2

Product Clone Name: 4C1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 289-388

Epitope Target: DGAT2

Epitope Species: human

Product Reactivity/Detection: DGAT2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 19 citations in various scientific publications

Available Conjugates/Forms for DGAT2 Antibody (4C1): N/A