DGAT1 Antibody (G-6): sc-271935

DGAT1 Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects DGAT1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DGAT1, also known as acyl-coenzyme A:diacylglycerol acyltransferase, is a crucial microsomal enzyme that catalyzes the final and committed step in the synthesis of triacylglycerol, utilizing diacylglycerol and fatty acyl CoA as substrates. This enzyme plays a vital role in lipid metabolism, particularly in the conversion of excess carbohydrates into triglycerides, which are essential for efficient energy storage. The proper functioning of DGAT1 is critical for various physiological processes, including intestinal fat absorption, lipoprotein assembly, and adipose tissue formation. Notably, DGAT1 is predominantly expressed in adipose tissue, where DGAT1 contributes to basal triglyceride synthesis, and DGAT1 absence in mice leads to increased energy expenditure and resistance to obesity. Furthermore, DGAT1 deficiency results in a complete inability to secrete milk in these mice, highlighting DGAT1′s importance in triglyceride synthesis within the mammary gland. anti-DGAT1 antibody (G-6) is an invaluable tool for researchers studying lipid metabolism and related disorders, providing insights into the mechanisms underlying energy storage and utilization in human physiology.

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DGAT1 Antibody (G-6) References:

1. Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.  |  Chen, HC. and Farese, RV. 2005. Arterioscler Thromb Vasc Biol. 25: 482-6. PMID: 15569818
2. Directed evolution of DGAT1 to increase triacylglycerol content.  |  McCormick, S. 2017. Plant J. 92: 165-166. PMID: 28994204
3. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.  |  Graham, KL., et al. 2019. Proc Natl Acad Sci U S A. 116: 3126-3135. PMID: 30718413
4. DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis.  |  Huang, JS., et al. 2021. Acta Pharmacol Sin. 42: 264-271. PMID: 32737468
5. DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis.  |  Xia, L., et al. 2021. J Immunol Res. 2021: 6636791. PMID: 34095320
6. DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion.  |  Long, M., et al. 2022. EMBO J. 41: e109390. PMID: 35411952
7. The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis.  |  Moorey, AR. and Besra, GS. 2022. Cell Surf. 8: 100083. PMID: 36277080
8. Rotavirus-mediated DGAT1 degradation: A pathophysiological mechanism of viral-induced malabsorptive diarrhea.  |  Liu, Z., et al. 2023. Proc Natl Acad Sci U S A. 120: e2302161120. PMID: 38079544
9. Prevention of lipid droplet accumulation by DGAT1 inhibition ameliorates sepsis-induced liver injury and inflammation.  |  Teixeira, L., et al. 2024. JHEP Rep. 6: 100984. PMID: 38293685
10. The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.  |  Deng, B., et al. 2024. J Transl Med. 22: 290. PMID: 38500157

The preferred DGAT1 antibody is DGAT1 Antibody (A-5): sc-271934.