Desmin Antibody (D33): sc-58744
- Desmin Antibody (D33) is a mouse monoclonal IgG1, cited in 4 publications, provided at 500 µl supernatant
- raised against leiomyoma cells of human origin
- recommended for detection of the 52kDa Desmin of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Desmin (RD301): sc-23879 for Desmin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Desmin Antibody (D33). This work is in progress.
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Desmin Antibody (D33) is a mouse monoclonal IgG1 antibody that detects Desmin from mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Desmin antibody (D33) is available in a non-conjugated form, providing flexibility for various experimental needs. Desmin, a 469 amino acid protein, plays a crucial role in maintaining the structural integrity of muscle cells by forming a network of intermediate filaments that connect to the Z line in sarcomeres. This structural arrangement is vital for muscle contraction and force transmission, as Desmin helps to stabilize the myofibrils during muscle activity. Proper functioning of Desmin is essential for muscle health, and mutations in the gene encoding Desmin can lead to severe conditions such as adult-onset skeletal myopathy and cardiac issues. Desmin (D33) antibody enables researchers to effectively study Desmin expression and localization in various tissues, contributing to a better understanding of muscle-related diseases and the cellular mechanisms underlying muscle development and maintenance.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Desmin Antibody (D33) References:
- Desmin cytoskeleton: a potential regulator of muscle mitochondrial behavior and function. | Capetanaki, Y. 2002. Trends Cardiovasc Med. 12: 339-48. PMID: 12536120
- Desmin cytoskeleton in healthy and failing heart. | Capetanaki, Y. 2000. Heart Fail Rev. 5: 203-20. PMID: 16228905
- Posttranslational modifications of desmin and their implication in biological processes and pathologies. | Winter, DL., et al. 2014. Histochem Cell Biol. 141: 1-16. PMID: 24091796
- Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle. | Zhang, H., et al. 2021. JCI Insight. 6: PMID: 34494555
- Desmin Modulates Muscle Cell Adhesion and Migration. | Hakibilen, C., et al. 2022. Front Cell Dev Biol. 10: 783724. PMID: 35350386
- Desmin Myopathy-A Masquerader of Infantile-Onset Pompe Disease. | Rauf, A., et al. 2022. Indian J Pediatr. 89: 925. PMID: 35779230
- Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte. | Salomon, AK., et al. 2022. Basic Res Cardiol. 117: 53. PMID: 36326891
- Host Desmin Interacts with RABV Matrix Protein and Facilitates Virus Propagation. | Zhang, W., et al. 2023. Viruses. 15: PMID: 36851648
- Desmin mutations impact the autophagy flux in C2C12 cell in mutation-specific manner. | Sukhareva, KS., et al. 2023. Cell Tissue Res. 393: 357-375. PMID: 37277577
- Phenotype and Clinical Outcomes in Desmin-Related Arrhythmogenic Cardiomyopathy. | Bermudez-Jimenez, FJ., et al. 2024. JACC Clin Electrophysiol. 10: 1178-1190. PMID: 38727660
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desmin Antibody (D33) | sc-58744 | 500 µl supernatant | $322.00 |