Derlin-1 Antibody (1B9): sc-293385

Derlin-1 Antibody (1B9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Derlin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Derlin-1 antibody (1B9) is available as a non-conjugated format. Derlin-1 plays a critical role in the endoplasmic reticulum-associated degradation (ERAD) pathway, which is essential for maintaining cellular homeostasis by ensuring that misfolded proteins are efficiently identified and targeted for degradation. This process is vital because the accumulation of misfolded proteins can lead to cellular stress and contribute to various diseases, including neurodegenerative disorders and cancer. Derlin-1 is primarily localized in the endoplasmic reticulum, where Derlin-1 facilitates the translocation of misfolded proteins from the ER to the cytosol, allowing them to be ubiquitinated and subsequently degraded by the proteasome. Notably, during cytomegalovirus infection, Derlin-1 specifically interacts with viral protein US11 to aid in the export of MHC class I heavy chains from the ER, highlighting Derlin-1′s importance in both viral pathogenesis and immune response. Derlin-1 is widely expressed across various tissues, with highest levels found in the spleen, pancreas, lung, liver, thymus, and ovary, and Derlin-1′s dysregulation has been implicated in conditions such as hepatocarcinoma.

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Derlin-1 Antibody (1B9) References:

1. Cloning and characterization of F-LANa, upregulated in human liver cancer.  |  Ying, H., et al. 2001. Biochem Biophys Res Commun. 286: 394-400. PMID: 11500051
2. A membrane protein required for dislocation of misfolded proteins from the ER.  |  Lilley, BN. and Ploegh, HL. 2004. Nature. 429: 834-40. PMID: 15215855
3. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.  |  Ye, Y., et al. 2004. Nature. 429: 841-7. PMID: 15215856
4. The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum.  |  Katiyar, S., et al. 2005. Mol Biol Cell. 16: 4584-94. PMID: 16055502
5. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.  |  Lilley, BN. and Ploegh, HL. 2005. Proc Natl Acad Sci U S A. 102: 14296-301. PMID: 16186509
6. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.  |  Oda, Y., et al. 2006. J Cell Biol. 172: 383-93. PMID: 16449189
7. Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.  |  Loureiro, J., et al. 2006. Nature. 441: 894-7. PMID: 16738546

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Derlin-1 Antibody (1B9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Derlin-1 Antibody (1B9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Derlin-1 Antibody (1B9) Specifications

Alternate Product Name: Derlin-1

Product Clone Name: 1B9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 134-233

Epitope Target: Derlin-1

Epitope Species: human

Product Reactivity/Detection: Derlin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Derlin-1 Antibody (1B9): N/A