DECR1 Antibody (G-10): sc-393473

DECR1 Antibody (G-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects DECR1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). DECR1 (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DECR1, or 2,4-dienoyl-CoA reductase, mitochondrial, is a crucial 335 amino acid mitochondrial protein that plays a significant role in the metabolism of unsaturated fatty acids. DECR1 is expressed in vital tissues such as the heart, pancreas, liver, lung, kidney, and skeletal muscle, where DECR1 functions as an auxiliary enzyme in the beta-oxidation pathway. This process is essential for energy production, as DECR1 breaks down acyl-CoA to generate Acetyl-CoA, the primary substrate for the Krebs cycle. DECR1 catalyzes the reduction of 2,4-dienoyl-CoA to trans-3-enoyl-CoA using NADP+, facilitating the conversion of unsaturated fatty acids into forms that can be utilized for energy. DECR1 is believed to have tumor suppressor properties, potentially inhibiting the expression of oncogenes such as Neu, thereby contributing to the regulation of tumorigenesis.

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DECR1 Antibody (G-10) References:

1. Cloning, expression, and purification of the functional 2,4-dienoyl-CoA reductase from rat liver mitochondria.  |  Fillgrove, KL., et al. 1999. Protein Expr Purif. 17: 57-63. PMID: 10497069
2. The mechanism of dienoyl-CoA reduction by 2,4-dienoyl-CoA reductase is stepwise: observation of a dienolate intermediate.  |  Fillgrove, KL. and Anderson, VE. 2001. Biochemistry. 40: 12412-21. PMID: 11591162
3. Metabolic functions of the two pathways of oleate beta-oxidation double bond metabolism during the beta-oxidation of oleic acid in rat heart mitochondria.  |  Ren, Y. and Schulz, H. 2003. J Biol Chem. 278: 111-6. PMID: 12397064
4. Studies of human mitochondrial 2,4-dienoyl-CoA reductase.  |  Yu, W., et al. 2005. Arch Biochem Biophys. 434: 195-200. PMID: 15629123
5. Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.  |  Ursini-Siegel, J., et al. 2007. Mol Cell Biol. 27: 6361-71. PMID: 17636013
6. Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes.  |  Kardon, T., et al. 2008. FEBS Lett. 582: 1809-15. PMID: 18472006
7. 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation.  |  Roe, CR., et al. 1990. J Clin Invest. 85: 1703-7. PMID: 2332510
8. Isolation and characterization of cDNA for human 120 kDa mitochondrial 2,4-dienoyl-coenzyme A reductase.  |  Koivuranta, KT., et al. 1994. Biochem J. 304 (Pt 3): 787-92. PMID: 7818482
9. Molecular cloning and characterization of the human mitochondrial 2,4-dienoyl-CoA reductase gene (DECR).  |  Helander, HM., et al. 1997. Genomics. 46: 112-9. PMID: 9403065

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DECR1 Antibody (G-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DECR1 Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DECR1 Antibody (G-10) Specifications

Alternate Product Name: DECR1

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 90-335

Epitope Target: DECR1

Epitope Species: human

Product Reactivity/Detection: DECR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DECR1 Antibody (G-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin