Decorin Antibody (888E12): sc-47771
- Decorin Antibody (888E12) is a mouse monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against Decorin of human origin
- recommended for detection of Decorin of human origin by WB, IF, IHC(P) and ELISA; also reactive with additional species, including bovine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Decorin Antibody (888E12). This work is in progress.
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Decorin Antibody (888E12) is a mouse monoclonal IgG1 antibody that detects Decorin in human samples through applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Decorin is a small leucine-rich proteoglycan (SLRP) that plays a crucial role in the extracellular matrix by binding to collagen types I, II, and IV, which is essential for maintaining the structural integrity and mechanical properties of tissues. The Decorin core protein, consisting of ten leucine-rich repeats, is involved in collagen fiber formation and interacts with various growth factors and matrix molecules, including fibronectin and thrombospondin, thereby influencing cellular behavior and tissue repair processes. Decorin acts as a negative regulator of transforming growth factor beta (TGFβ), which is significant in modulating inflammatory responses and fibrosis. The human Decorin gene is located on chromosome 12q21.33 and encodes a 359 amino acid protein, highlighting Decorin′s importance in both normal physiology and pathological conditions, such as inflammatory joint diseases where Decorin expression may be inhibited, leading to cartilage destruction. Anti-Decorin antibody (888E12) serves as an invaluable tool for researchers studying Decorin′s roles in various biological processes and disease mechanisms.
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Decorin Antibody (888E12) References:
- The galactosaminoglycan-containing decorin and its impact on diseases. | Seidler, DG. 2012. Curr Opin Struct Biol. 22: 578-82. PMID: 22877511
- Decorin treatment of spinal cord injury. | Esmaeili, M., et al. 2014. Neural Regen Res. 9: 1653-6. PMID: 25374584
- Pivotal role for decorin in angiogenesis. | Järveläinen, H., et al. 2015. Matrix Biol. 43: 15-26. PMID: 25661523
- Decorin as a multivalent therapeutic agent against cancer. | Neill, T., et al. 2016. Adv Drug Deliv Rev. 97: 174-85. PMID: 26522384
- Decorin in the Tumor Microenvironment. | Baghy, K., et al. 2020. Adv Exp Med Biol. 1272: 17-38. PMID: 32845500
- The Role of Decorin Proteoglycan in Mitophagy. | Neill, T. and Iozzo, RV. 2022. Cancers (Basel). 14: PMID: 35159071
- The Role of Decorin in Autoimmune and Inflammatory Diseases. | Dong, Y., et al. 2022. J Immunol Res. 2022: 1283383. PMID: 36033387
- Role of Decorin in the Lens and Ocular Diseases. | Kubo, E., et al. 2022. Cells. 12: PMID: 36611867
- Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis. | Lin, Y., et al. 2023. J Exp Clin Cancer Res. 42: 172. PMID: 37464382
- Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression. | Mondal, DK., et al. 2024. Proc Natl Acad Sci U S A. 121: e2317760121. PMID: 38652741
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Decorin Antibody (888E12) | sc-47771 | 200 µg/ml | $316.00 |