DDX30 Antibody (D-9): sc-390663

DDX30 Antibody (D-9) is a mouse monoclonal IgM antibody that detects DDX30 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DDX30 antibody (D-9) is available as the non-conjugated form. DDX30, also known as DEAH box protein 30, is a 1,194 amino acid protein that plays a crucial role in mitochondrial DNA replication by forming a complex with mitochondrial transcription factor A (TFAM) and single-stranded DNA-binding protein 1 (SSBP1) in the mitochondria. This interaction is vital for maintaining mitochondrial function and integrity, as DDX30 ensures proper replication and transcription of mitochondrial DNA, which is essential for energy production and cellular metabolism. Additionally, DDX30 is characterized by the conserved DEAD box motif, which indicates function as a putative RNA helicase involved in various cellular processes, including translation initiation and RNA splicing. The presence of two isoforms of DDX30, resulting from alternative splicing, further highlights the complexity and regulatory potential in cellular activities. With diverse applications in research, DDX30 (D-9) antibody serves as an invaluable tool for studying the intricate roles of DDX30 in cellular processes and mitochondrial dynamics.

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DDX30 Antibody (D-9) References:

1. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily.  |  Fu, JJ., et al. 2002. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 34: 655-61. PMID: 12198572
2. Expression research for human DDX36 and mouse Ddx36 gene in the adult testis.  |  Fu, JJ., et al. 2003. Yi Chuan Xue Bao. 30: 201-8. PMID: 12812084
3. RNA helicases: regulators of differentiation.  |  Abdelhaleem, M. 2005. Clin Biochem. 38: 499-503. PMID: 15885226
4. The DEAD-box protein family of RNA helicases.  |  Cordin, O., et al. 2006. Gene. 367: 17-37. PMID: 16337753
5. Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane.  |  Wang, Y. and Bogenhagen, DF. 2006. J Biol Chem. 281: 25791-802. PMID: 16825194
6. Dead-box proteins: a family affair--active and passive players in RNP-remodeling.  |  Linder, P. 2006. Nucleic Acids Res. 34: 4168-80. PMID: 16936318
7. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.  |  Cantin, GT., et al. 2008. J Proteome Res. 7: 1346-51. PMID: 18220336
8. The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators.  |  Fuller-Pace, FV. and Ali, S. 2008. Biochem Soc Trans. 36: 609-12. PMID: 18631126
9. Fluorescence methods in the investigation of the DEAD-box helicase mechanism.  |  Andreou, AZ. and Klostermeier, D. 2014. Exp Suppl. 105: 161-92. PMID: 25095995
10. DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.  |  Tajirika, T., et al. 2018. Int J Mol Sci. 19: PMID: 29987267
11. DDX41: a multifunctional DEAD-box protein involved in pre-mRNA splicing and innate immunity.  |  Andreou, AZ. 2021. Biol Chem. 402: 645-651. PMID: 33711218
12. The clinical and genomic landscape of patients with DDX41 variants identified during diagnostic sequencing.  |  Maierhofer, A., et al. 2023. Blood Adv. 7: 7346-7357. PMID: 37874914

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DDX30 Antibody (D-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DDX30 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DDX30 Antibody (D-9) Specifications

Alternate Product Name: DHX30

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 306-335

Epitope Target: DDX30

Epitope Species: human

Product Reactivity/Detection: DDX30

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DDX30 Antibody (D-9): P: Blocking Peptide