DDR1 Antibody (C-6): sc-374618

DDR1 Antibody (C-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects DDR1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDR1 (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DDR1, also known as discoidin domain receptor tyrosine kinase 1, plays a crucial role in mediating cellular responses to the extracellular matrix, particularly collagen, which is vital for tissue development and repair. Upon activation by collagen, DDR1 initiates signaling pathways that influence cell adhesion, migration, and proliferation, thereby contributing to processes such as wound healing and fibrosis. DDR1′s function is highlighted by involvement in various pathological conditions, including cancer and fibrotic diseases, where dysregulation of receptor tyrosine kinases can lead to aberrant cellular behavior. Understanding DDR1′s role in these processes can provide insights into potential therapeutic targets for treating related diseases.

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DDR1 Antibody (C-6) References:

1. Growth factors and cancer.  |  Aaronson, SA. 1991. Science. 254: 1146-53. PMID: 1659742
2. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.  |  Huang, E., et al. 1990. Cell. 63: 225-33. PMID: 1698557
3. Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor.  |  Krämer, H., et al. 1991. Nature. 352: 207-12. PMID: 1857416
4. Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development.  |  Pawson, T. and Bernstein, A. 1990. Trends Genet. 6: 350-6. PMID: 1965067
5. Signal transduction by receptors with tyrosine kinase activity.  |  Ullrich, A. and Schlessinger, J. 1990. Cell. 61: 203-12. PMID: 2158859
6. Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis.  |  Wang, J., et al. 2022. Bioact Mater. 17: 406-424. PMID: 35386458
7. Blockade of DDR1/PYK2/ERK signaling suggesting SH2 superbinder as a novel autophagy inhibitor for pancreatic cancer.  |  Xu, H., et al. 2023. Cell Death Dis. 14: 811. PMID: 38071340
8. DDR1 promotes metastasis of cervical cancer and downstream phosphorylation signal via binding GRB2.  |  Zhang, J., et al. 2024. Cell Death Dis. 15: 849. PMID: 39567474
9. The role of DDR1 in cancer and the progress of its selective inhibitors.  |  Wang, J., et al. 2025. Bioorg Chem. 154: 108018. PMID: 39642752
10. Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.  |  Perez, JL., et al. 1994. Oncogene. 9: 211-9. PMID: 8302582
11. The discoidin domain receptor tyrosine kinases are activated by collagen.  |  Vogel, W., et al. 1997. Mol Cell. 1: 13-23. PMID: 9659899
12. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.  |  Shrivastava, A., et al. 1997. Mol Cell. 1: 25-34. PMID: 9659900

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DDR1 Antibody (C-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-DDR1 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DDR1 Antibody (C-6) Specifications

Alternate Product Name: Discoidin Domain Receptor 1 (DDR1)

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 894-913

Epitope Target: DDR1

Epitope Species: human

Product Reactivity/Detection: DDR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for DDR1 Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin