DDC Antibody (8E8): sc-293287

DDC Antibody (8E8) is a mouse monoclonal IgG2a kappa light chain antibody that detects DDC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DDC antibody (8E8) is available as the non-conjugated format. DOPA decarboxylase (DDC), also known as aromatic-L-amino-acid decarboxylase (AADC), is a crucial enzyme in the catecholamine biosynthesis pathway, playing a vital role in converting L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin, and L-tryptophan to tryptamine. DDC (8E8) antibody localizes primarily in the cytoplasm of neurons and neuroendocrine cells, where efficient synthesis of neurotransmitters regulates mood, cognition, and various physiological processes. Defects in the gene encoding DDC can lead to AADC deficiency, a serious autosomal recessive disorder characterized by neurological symptoms, including poor feeding, developmental delays, and gastrointestinal disturbances. DDC′s ability to form homodimers further underscores DDC′s importance in maintaining neurotransmitter balance, making DDC (8E8) monoclonal antibody a valuable tool for researchers studying neurotransmitter metabolism and related disorders.

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DDC Antibody (8E8) References:

1. Localisation of the gene for human aromatic L-amino acid decarboxylase (DDC) to chromosome 7p13-->p11 by in situ hybridisation.  |  Craig, SP., et al. 1992. Cytogenet Cell Genet. 61: 114-6. PMID: 1395716
2. Levodopa-responsive aromatic L-amino acid decarboxylase deficiency.  |  Chang, YT., et al. 2004. Ann Neurol. 55: 435-8. PMID: 14991824
3. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis.  |  Sumi-Ichinose, C., et al. 1992. Biochemistry. 31: 2229-38. PMID: 1540578
4. Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA.  |  Vassilacopoulou, D., et al. 2004. Neurochem Res. 29: 1817-23. PMID: 15532536
5. Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.  |  Ma, JZ., et al. 2005. Hum Mol Genet. 14: 1691-8. PMID: 15879433
6. Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs.  |  Scherer, LJ., et al. 1992. Genomics. 13: 469-71. PMID: 1612608
7. Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer.  |  Avgeris, M., et al. 2008. Clin Biochem. 41: 1140-9. PMID: 18586020
8. Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo.  |  Eisenberg, DP., et al. 2016. Neuropsychopharmacology. 41: 2303-8. PMID: 26924680
9. Multi-omics profiles refine L-dopa decarboxylase (DDC) as a reliable biomarker for prognosis and immune microenvironment of clear cell renal cell carcinoma.  |  Chang, K., et al. 2022. Front Oncol. 12: 1079446. PMID: 36544704
10. Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress.  |  Lotsios, NS., et al. 2023. Curr Issues Mol Biol. 45: 10179-10192. PMID: 38132481
11. Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease.  |  Rutledge, J., et al. 2024. Acta Neuropathol. 147: 52. PMID: 38467937
12. Identification of a neuron-specific promoter of human aromatic L-amino acid decarboxylase gene.  |  Le Van Thai, A., et al. 1993. Brain Res Mol Brain Res. 17: 227-38. PMID: 8510497

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DDC Antibody (8E8) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-DDC Antibody (8E8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DDC Antibody (8E8) Specifications

Alternate Product Name: DDC

Product Clone Name: 8E8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-480

Epitope Target: DDC

Epitope Species: human

Product Reactivity/Detection: DDC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for DDC Antibody (8E8): N/A