DCIR Antibody (G-9): sc-374583

DCIR Antibody (G-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects DCIR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DCIR (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DCIR, or dendritic cell immunoreceptor, is a type II membrane glycoprotein characterized by a single carbohydrate recognition domain (CRD) and is closely related to macrophage lectin and hepatic asialoglycoprotein receptors. DCIR′s intracellular domain features a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM), which plays a crucial role in modulating cellular responses, such as protein tyrosine phosphorylation and B-cell receptor-mediated calcium mobilization. The presence of the phosphorylated ITIM motif allows for the binding of SH2 domain-containing phosphatases, thereby influencing various signaling pathways. DCIR is predominantly expressed on dendritic cells, monocytes, macrophages, B lymphocytes, and granulocytes, but is notably absent in natural killer and T cells. Importantly, DCIR expression on dendritic cells is downregulated in response to maturation signals, such as lipopolysaccharides, tumor necrosis factor-alpha, or CD40 stimulation, highlighting its role in immune regulation and the potential impact on dendritic cell function during immune responses.

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DCIR Antibody (G-9) References:

1. Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants.  |  Huang, X., et al. 2001. Biochem Biophys Res Commun. 281: 131-40. PMID: 11178971
2. The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation.  |  Richard, M., et al. 2002. J Leukoc Biol. 71: 871-80. PMID: 11994513
3. Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain.  |  Kanazawa, N., et al. 2003. J Biol Chem. 278: 32645-52. PMID: 12777403
4. The ITIM-bearing CLECSF6 (DCIR) is down-modulated in neutrophils by neutrophil activating agents.  |  Richard, M., et al. 2003. Biochem Biophys Res Commun. 310: 767-73. PMID: 14550269
5. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex.  |  Flornes, LM., et al. 2004. Immunogenetics. 56: 506-17. PMID: 15368084
6. A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro.  |  Velten, FW., et al. 2004. Eur J Immunol. 34: 2800-11. PMID: 15368296
7. Signaling and immune regulatory role of the dendritic cell immunoreceptor (DCIR) family lectins: DCIR, DCAR, dectin-2 and BDCA-2.  |  Kanazawa, N., et al. 2004. Immunobiology. 209: 179-90. PMID: 15481152
8. Continuous EEG detection of DCI and seizures following aSAH: a systematic review.  |  Guo, Y., et al. 2020. Br J Neurosurg. 34: 543-548. PMID: 31208250
9. The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios.  |  Nordio, M., et al. 2019. Eur Rev Med Pharmacol Sci. 23: 5512-5521. PMID: 31298405
10. Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis.  |  Rehman, S., et al. 2023. Acta Neurochir (Wien). 165: 199-210. PMID: 36333624
11. Therapies for Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage.  |  Shah, VA., et al. 2023. Neurocrit Care. 39: 36-50. PMID: 37231236
12. What are the predictors of delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage? An up-to-date systematic review.  |  Whittle, C., et al. 2023. Acta Neurochir (Wien). 165: 3643-3650. PMID: 37968365

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DCIR Antibody (G-9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-DCIR Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DCIR Antibody (G-9) Specifications

Alternate Product Name: DCIR

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 191-237

Epitope Target: DCIR

Epitope Species: human

Product Reactivity/Detection: DCIR isoforms 1-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for DCIR Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin