DCAMKL1 Antibody (D-3): sc-514684

DCAMKL1 Antibody (D-3) is a mouse monoclonal IgM antibody that detects DCAMKL1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DCAMKL1 antibody (D-3) is available as a non-conjugated format. DCAMKL1, also known as doublecortin-like and CAM kinase-like 1, plays a crucial role in neuronal development and function, particularly in regulating microtubule dynamics during neuronal migration. DCAMKL1 is highly expressed in the developing brain, where DCAMKL1 interacts with other key proteins such as doublecortin and lissencephaly-1 protein (LIS1), both implicated in lissencephaly, a severe brain malformation characterized by incomplete neuronal migration. DCAMKL1′s interaction with these proteins is essential for proper neuronal positioning and brain architecture, highlighting DCAMKL1′s importance in neurodevelopmental processes. Additionally, DCAMKL1 encodes a functional kinase capable of phosphorylating myelin basic protein and itself, although DCAMKL1′s kinase activity doesn′t directly influence microtubule polymerization. This multifaceted role of DCAMKL1 underscores DCAMKL1′s significance in maintaining neuronal integrity and function, making DCAMKL1 a valuable target for research in neurodevelopmental disorders.

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DCAMKL1 Antibody (D-3) References:

1. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX).  |  Sossey-Alaoui, K. and Srivastava, AK. 1999. Genomics. 56: 121-6. PMID: 10036192
2. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).  |  Matsumoto, N., et al. 1999. Genomics. 56: 179-83. PMID: 10051403
3. Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression.  |  Manabe, M., et al. 1999. Arch Dermatol. 135: 177-81. PMID: 10052403
4. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.  |  Lin, PT., et al. 2000. J Neurosci. 20: 9152-61. PMID: 11124993
5. The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2.  |  Zou, W., et al. 2013. J Exp Med. 210: 1793-806. PMID: 23918955
6. DCAMKL1 is associated with the malignant status and poor outcome in bladder cancer.  |  Zhang, S., et al. 2017. Tumour Biol. 39: 1010428317703822. PMID: 28621231
7. Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.  |  Reiner, O., et al. 1993. Nature. 364: 717-21. PMID: 8355785
8. Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.  |  Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
9. Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor.  |  Albrecht, U., et al. 1996. Dev Biol. 180: 579-93. PMID: 8954729
10. A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome.  |  des Portes, V., et al. 1998. Cell. 92: 51-61. PMID: 9489699
11. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.  |  Gleeson, JG., et al. 1998. Cell. 92: 63-72. PMID: 9489700
12. LISsen up!  |  Walsh, CA. 1998. Nat Genet. 19: 307-8. PMID: 9697681

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DCAMKL1 Antibody (D-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DCAMKL1 Antibody (D-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DCAMKL1 Antibody (D-3) Specifications

Alternate Product Name: DCAMKL1

Product Clone Name: D-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 19-38

Epitope Target: DCAMKL1

Epitope Species: mouse

Product Reactivity/Detection: DCAMKL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DCAMKL1 Antibody (D-3): P: Blocking Peptide