D4DR Antibody (2B9): sc-136169

D4DR Antibody (2B9) is a mouse monoclonal IgG antibody that detects D4DR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-D4DR antibody (2B9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. D4DR protein, a member of the dopamine receptor family, plays a crucial role in neurotransmission and is primarily located in the central nervous system, particularly in areas associated with mood regulation and cognitive functions. D4DR localization influences the modulation of dopaminergic signaling pathways, which are essential for various physiological processes, including reward, motivation, and motor control. Dysregulation of D4DR signaling has been implicated in several neuropsychiatric disorders, making D4DR a vital target for therapeutic interventions. D4DR receptor is part of the D2 subclass of dopamine receptors, which also includes D2DR and D3DR, and D4DR′s unique signaling properties contribute to the complexity of dopamine-related functions in the brain.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

D4DR Antibody (2B9) References:

1. Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants.  |  Auerbach, J., et al. 1999. Mol Psychiatry. 4: 369-73. PMID: 10483054
2. Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line.  |  Hayes, G., et al. 1992. Mol Endocrinol. 6: 920-6. PMID: 1323056
3. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.  |  Hausdorff, WP., et al. 1990. Symp Soc Exp Biol. 44: 225-40. PMID: 1983369
4. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.  |  Cotecchia, S., et al. 1990. J Biol Chem. 265: 63-9. PMID: 2152928
5. Attention-deficit/hyperactivity disorder and dopamine receptor D4 (DRD4) exon 3 variable number of tandem repeats (VNTR) 2-repeat allele.  |  Baum, L., et al. 2024. Ann Hum Genet. 88: 382-391. PMID: 38624263
6. Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization.  |  Ng, GY., et al. 1995. Proc Natl Acad Sci U S A. 92: 10157-61. PMID: 7479745
7. The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.  |  Barak, LS., et al. 1995. Biochemistry. 34: 15407-14. PMID: 7492540
8. Molecular and chemical neuropharmacology of dopamine receptor subtypes.  |  Ogawa, N. 1995. Acta Med Okayama. 49: 1-11. PMID: 7762403
9. The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.  |  Senogles, SE. 1994. J Biol Chem. 269: 23120-7. PMID: 7916015
10. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking.  |  Ebstein, RP., et al. 1996. Nat Genet. 12: 78-80. PMID: 8528256
11. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.  |  Ebstein, RP., et al. 1997. Am J Med Genet. 74: 65-72. PMID: 9034010
12. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects.  |  Kotler, M., et al. 1997. Mol Psychiatry. 2: 251-4. PMID: 9152990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-D4DR Antibody (2B9) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-D4DR Antibody (2B9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

D4DR Antibody (2B9) Specifications

Alternate Product Name: D4DR

Product Clone Name: 2B9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG kappa light chain

Amino Acids: 176-185

Epitope Target: D4DR

Epitope Species: human

Product Reactivity/Detection: D4DR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for D4DR Antibody (2B9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin