Cytokeratin 6 Antibody (Ks6.KA12): sc-58735

Cytokeratin 6 Antibody (Ks6.KA12) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 6 in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 6 is a vital member of the cytokeratin family, which consists of intermediate filament proteins that are crucial for maintaining the structural integrity and function of epithelial cells. These proteins are predominantly located in the cytoplasm of epithelial cells, where they form a network that provides mechanical support and resilience against stress. The presence of Cytokeratin 6 is particularly important in the epidermis, as Cytokeratin 6 constitutes a significant portion of the keratinocyte population, contributing to the barrier function of the skin. Additionally, anti-Cytokeratin 6 antibody (Ks6.KA12) serves as a marker for epithelial differentiation and is instrumental in the diagnosis and characterization of various malignant tumors, making Cytokeratin 6 (Ks6.KA12) monoclonal antibody a valuable tool in both research and clinical settings. The gene encoding human Cytokeratin 6A, the dominant isoform in epithelial tissues, is located on chromosome 12q13, and mutations in this gene can lead to a range of inherited skin and hair disorders. Anti-Cytokeratin 6 antibody (Ks6.KA12) is therefore an essential reagent for studying epithelial biology and pathology, providing insights into both normal and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Cytokeratin 6 Antibody (Ks6.KA12) References:

1. A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath.  |  Aoki, N., et al. 2001. J Invest Dermatol. 116: 359-65. PMID: 11231308
2. A human folliculoid microsphere assay for exploring epithelial- mesenchymal interactions in the human hair follicle.  |  Havlickova, B., et al. 2009. J Invest Dermatol. 129: 972-83. PMID: 18923448
3. Acute sensitivity of the oral mucosa to oncogenic K-ras.  |  van der Weyden, L., et al. 2011. J Pathol. 224: 22-32. PMID: 21381032
4. Immune responses elicited in rainbow trout through the administration of infectious pancreatic necrosis virus-like particles.  |  Martinez-Alonso, S., et al. 2012. Dev Comp Immunol. 36: 378-84. PMID: 21893091
5. Immunohistochemical profile of cytokeratins in pseudoepitheliomatous hyperplasia of cutaneous leishmaniasis.  |  Viana, AG., et al. 2011. Int J Dermatol. 50: 1470-4. PMID: 22097991
6. Synovial cysts of the lumbar spine--pathological considerations and surgical strategy.  |  Ganau, M., et al. 2013. Neurol Med Chir (Tokyo). 53: 95-102. PMID: 23438660
7. Ultraviolet B irradiation induces the expression of hornerin in xenotransplanted human skin.  |  Makino, T., et al. 2014. Acta Histochem. 116: 20-4. PMID: 23751202
8. Topical application of the adenosine A2A receptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice.  |  Arasa, J., et al. 2014. Exp Dermatol. 23: 555-60. PMID: 24889129
9. Changes in the expression of epidermal differentiation markers at sites where cultured epithelial autografts were transplanted onto wounds from burn scar excision.  |  Kadoya, K., et al. 2016. Int Wound J. 13: 412-7. PMID: 25040836
10. Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content.  |  Miyake, H., et al. 2016. Invest Ophthalmol Vis Sci. 57: 3268-75. PMID: 27327582

The preferred Cytokeratin 6/75 antibody is Cytokeratin 6/75 Antibody (H-6): sc-166074.