Cytokeratin 5/6/18 Antibody (3H2061): sc-70926

Cytokeratin 5/6/18 Antibody (3H2061) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 5/6/18 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 5/6/18 is a crucial component of the cytoskeletal structure in epithelial cells, playing a significant role in maintaining cellular integrity and providing mechanical support. Anti-Cytokeratin 5/6/18 antibody (3H2061) serves as a reliable marker for identifying specific epithelial cell types and their states, especially in the diagnosis of malignant tumors. Cytokeratin 5 is predominantly expressed in basal cells, while Cytokeratin 6 is found in suprabasal keratinocytes, particularly during wound healing, and Cytokeratin 18 is one of the earliest keratins expressed during embryonic development, persisting in adult simple epithelia and adenocarcinomas. The interaction of these cytokeratins with other proteins, such as desmoplakin and plectin, is vital for the formation of desmosomes and hemidesmosomes, which are essential for cell adhesion and tissue stability. Understanding the expression and interaction of Cytokeratin 5/6/18 can provide insights into various pathological conditions, including epidermolysis bullosa, where mutations in the cytokeratin 5 gene lead to significant skin fragility.

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.