Cytokeratin 5/14 Antibody (2Q1049): sc-70922

Cytokeratin 5/14 Antibody (2Q1049) is a mouse monoclonal IgM antibody that detects Cytokeratin 5/14 of human origin by immunofluorescence (IF). Anti-Cytokeratin 5/14 antibody (2Q1049) is available as a non-conjugated format. Cytokeratin 5 and Cytokeratin 14 are crucial components of the cytoskeleton in epithelial cells, playing a significant role in maintaining cell integrity and providing mechanical support. These proteins are primarily located in the basal layer of stratified epithelia, where they contribute to the structural stability of tissues such as the skin and the lining of the esophagus. Their presence is vital for the resilience of epithelial tissues against mechanical stress and injury, and alterations in their expression can indicate various pathological conditions, including epithelial cancers. Expression patterns of Cytokeratin 5 and 14 are often utilized in clinical diagnostics to differentiate between various types of tumors, particularly in identifying squamous cell carcinomas. Using Cytokeratin 5/14 (2Q1049) antibody in immunofluorescence (IF) applications enables researchers to gain valuable insights into cellular architecture and pathology of epithelial tissues, enhancing understanding of both normal physiology and disease states.

The preferred Cytokeratin 14 antibody is Cytokeratin 14 Antibody (LL001): sc-53253.