Cytokeratin 5/14 Antibody (2Q1049): sc-70922

Cytokeratin 5/14 Antibody (2Q1049) is a mouse monoclonal IgM antibody that detects Cytokeratin 5/14 of human origin by immunofluorescence (IF). Anti-Cytokeratin 5/14 antibody (2Q1049) is available as a non-conjugated format. Cytokeratin 5 and Cytokeratin 14 are crucial components of the cytoskeleton in epithelial cells, playing a significant role in maintaining cell integrity and providing mechanical support. These proteins are primarily located in the basal layer of stratified epithelia, where they contribute to the structural stability of tissues such as the skin and the lining of the esophagus. Their presence is vital for the resilience of epithelial tissues against mechanical stress and injury, and alterations in their expression can indicate various pathological conditions, including epithelial cancers. Expression patterns of Cytokeratin 5 and 14 are often utilized in clinical diagnostics to differentiate between various types of tumors, particularly in identifying squamous cell carcinomas. Using Cytokeratin 5/14 (2Q1049) antibody in immunofluorescence (IF) applications enables researchers to gain valuable insights into cellular architecture and pathology of epithelial tissues, enhancing understanding of both normal physiology and disease states.

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Cytokeratin 5/14 Antibody (2Q1049) References:

1. BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia.  |  Linskey, KR., et al. 2013. Arch Pathol Lab Med. 137: 1591-8. PMID: 24168496
2. Expression of Cytokeratin 14 and 19 in Process of Oral Carcinogenesis.  |  Yoshida, K., et al. 2015. Bull Tokyo Dent Coll. 56: 105-11. PMID: 26084998
3. Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism.  |  Goodman, CR., et al. 2016. Oncogene. 35: 1373-85. PMID: 26096934
4. Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.  |  Gao, XL., et al. 2017. PLoS One. 12: e0171341. PMID: 28152077
5. Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer.  |  Abdelrahman, AE., et al. 2017. Ann Diagn Pathol. 28: 43-53. PMID: 28648939
6. Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice.  |  Watanabe, H., et al. 2017. Acta Histochem Cytochem. 50: 111-118. PMID: 28744028
7. β cells can be generated from cytokeratin 5-positive cells after cerulein-induced pancreatitis in adult mice.  |  Shi, Q., et al. 2018. Biochem Biophys Res Commun. 496: 114-119. PMID: 29307825
8. Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.  |  Li, YP., et al. 2018. Exp Biol Med (Maywood). 243: 344-349. PMID: 29350066
9. Diagnostic Utility of Cytokeratin-5 for the Identification of Proliferative Inflammatory Atrophy in the Canine Prostate.  |  Palmieri, C., et al. 2018. J Comp Pathol. 158: 1-5. PMID: 29422309
10. Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.  |  Tian, Q., et al. 2021. Hua Xi Kou Qiang Yi Xue Za Zhi. 39: 274-278. PMID: 34041875

The preferred Cytokeratin 14 antibody is Cytokeratin 14 Antibody (LL001): sc-53253.