Cytokeratin 23 Antibody (C-1): sc-365892
- Cytokeratin 23 Antibody (C-1) is a mouse monoclonal IgG1 κ Cytokeratin 23 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 161-290 mapping within an internal region of Cytokeratin 23 of human origin
- Cytokeratin 23 Antibody (C-1) is recommended for detection of Cytokeratin 23 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-Cytokeratin 23 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cytokeratin 23 Antibody (C-1) for WB applications. These reagents are now offered in bundles with Cytokeratin 23 Antibody (C-1) (see ordering information below).
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SEE ALSO...
Cytokeratin 23 Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 23 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Cytokeratin 23 antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 23, also known as KRT23, K23, CK23, or HAIK1, is a 422 amino acid intermediate filament protein that plays a crucial role in maintaining the structural integrity of epithelial cells. Cytokeratin 23 functions as a heterotetramer composed of two type I and two type II cytokeratins, which is essential for the mechanical stability of tissues. Cytokeratin 23 is primarily located in the cytoplasm of epithelial cells, where Cytokeratin 23 contributes to the formation of the cytoskeleton, providing resilience against mechanical stress. This structural role is particularly important in tissues that undergo significant stretching or deformation, such as the skin and certain glandular tissues. Notably, Cytokeratin 23 expression is upregulated in pancreatic cancer cells, indicating potential involvement in tumorigenesis and suggesting use as a biomarker for certain malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 23 Antibody (C-1) References:
- Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. | Zhang, JS., et al. 2001. Genes Chromosomes Cancer. 30: 123-35. PMID: 11135429
- Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. | Hesse, M., et al. 2001. J Cell Sci. 114: 2569-75. PMID: 11683385
- Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function. | Tolstonog, GV., et al. 2002. DNA Cell Biol. 21: 213-39. PMID: 12015898
- Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. | Suzuki, A., et al. 2004. Biochem Biophys Res Commun. 317: 887-92. PMID: 15081423
- New consensus nomenclature for mammalian keratins. | Schweizer, J., et al. 2006. J Cell Biol. 174: 169-74. PMID: 16831889
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 23 Antibody (C-1) | sc-365892 | 200 µg/ml | $316.00 | |||
Cytokeratin 23 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-527401 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cytokeratin 23 Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-532774 | 200 µg Ab; 20 µg BP | $354.00 | |||
Cytokeratin 23 Antibody (C-1) AC | sc-365892 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cytokeratin 23 Antibody (C-1) HRP | sc-365892 HRP | 200 µg/ml | $316.00 | |||
Cytokeratin 23 Antibody (C-1) FITC | sc-365892 FITC | 200 µg/ml | $330.00 | |||
Cytokeratin 23 Antibody (C-1) PE | sc-365892 PE | 200 µg/ml | $343.00 | |||
Cytokeratin 23 Antibody (C-1) Alexa Fluor® 488 | sc-365892 AF488 | 200 µg/ml | $357.00 | |||
Cytokeratin 23 Antibody (C-1) Alexa Fluor® 546 | sc-365892 AF546 | 200 µg/ml | $357.00 | |||
Cytokeratin 23 Antibody (C-1) Alexa Fluor® 594 | sc-365892 AF594 | 200 µg/ml | $357.00 | |||
Cytokeratin 23 Antibody (C-1) Alexa Fluor® 647 | sc-365892 AF647 | 200 µg/ml | $357.00 | |||
Cytokeratin 23 Antibody (C-1) Alexa Fluor® 680 | sc-365892 AF680 | 200 µg/ml | $357.00 | |||
Cytokeratin 23 Antibody (C-1) Alexa Fluor® 790 | sc-365892 AF790 | 200 µg/ml | $357.00 |