Cytokeratin 23 Inhibitors
Cytokeratins are a family of fibrous proteins that form the intermediate filaments within the cytoskeleton of epithelial cells. These proteins provide structural support and contribute to the mechanical integrity of epithelial tissues, including the skin, hair, and various internal organs. Cytokeratin 23, in particular, is one of the many isoforms within this protein family and is typically expressed in specific cell types, such as the epithelial cells of the esophagus and other stratified squamous epithelia.
Inhibitors of Cytokeratin 23 interact with this protein and potentially disrupt its filament-forming ability or affect its cellular functions. These inhibitors may operate through various mechanisms, such as binding to specific regions of Cytokeratin 23 or altering its conformation. By inhibiting Cytokeratin 23, these compounds can potentially impact the structural properties of epithelial cells and their ability to maintain tissue integrity. Research on Cytokeratin 23 inhibitors is primarily focused on unraveling the molecular functions of this particular cytokeratin isoform within epithelial tissues, providing insights into the complex organization and regulation of the cytoskeleton.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin from green tea that may modulate gene expression through epigenetic changes, potentially reducing KRT23 levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that can influence gene expression through sirtuin activation, possibly affecting KRT23 expression. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
A compound found in cruciferous vegetables that can modulate estrogen metabolism and gene expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A component of turmeric with known effects on signal transduction and gene expression, which may include KRT23. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An isothiocyanate from cruciferous vegetables that affects transcription factors and gene expression, potentially including KRT23. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that disrupts AKT signaling, possibly leading to altered KRT23 expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
A folate analog that inhibits dihydrofolate reductase, affecting nucleotide synthesis and possibly KRT23 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A histone deacetylase inhibitor that can alter chromatin structure, potentially affecting KRT23 gene expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glycolysis inhibitor that can create cellular stress, which might result in downregulation of KRT23 expression. | ||||||
Aminopterin | 54-62-6 | sc-202461 | 50 mg | $102.00 | 1 | |
A folic acid antagonist similar to methotrexate that can lead to reduced DNA, RNA, and protein synthesis, and may lower KRT23 expression. | ||||||