Cytokeratin 18 Antibody (LDK18): sc-53256
- Cytokeratin 18 Antibody (LDK18) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against an C-terminal synthetic peptide of Cytokeratin 18 of human origin
- recommended for detection of Cytokeratin 18 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Cytokeratin 18 (RGE53): sc-32329 for Cytokeratin 18 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cytokeratin 18 Antibody (LDK18) for WB and IHC(P) applications. These reagents are now offered in bundles with Cytokeratin 18 Antibody (LDK18) (see ordering information below).
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SEE ALSO...
Cytokeratin 18 Antibody (LDK18) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 18 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cytokeratin 18 is a vital component of the cytoskeleton in epithelial cells, contributing significantly to structural integrity and resilience. Cytokeratin 18 is predominantly located in the cytoplasm, forming a network of intermediate filaments that provide mechanical support and shape to cells. Proper localization of Cytokeratin 18 is crucial for maintaining epithelial tissue architecture, and disruption can lead to various pathological conditions, including cancer. Cytokeratin 18 serves as a biomarker for epithelial-derived tumors, as expression levels can indicate differentiation status of malignancies. Cytokeratin 18 undergoes post-translational modifications, including phosphorylation, which influences protein interactions and overall cellular function. Phosphorylation of specific serine residues, such as Ser 33 and Ser 52, is particularly important for Cytokeratin 18 stability and interaction with 14-3-3 proteins, which regulate cell signaling and cytoskeletal dynamics. Anti-Cytokeratin 18 antibody (LDK18) enables researchers to gain valuable insights into Cytokeratin 18′s role in both normal physiology and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 18 Antibody (LDK18) | sc-53256 | 200 µg/ml | $316.00 | |||
Cytokeratin 18 Antibody (LDK18): m-IgG Fc BP-HRP Bundle | sc-536918 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cytokeratin 18 Antibody (LDK18): m-IgGκ BP-HRP Bundle | sc-534091 | 200 µg Ab; 40 µg BP | $354.00 |