Cytokeratin 18 Antibody (DC-10): sc-6259

Cytokeratin 18 Antibody (DC-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Cytokeratin 18 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cytokeratin 18 antibody (DC-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cytokeratin 18 is a vital component of the cytoskeleton in epithelial cells, playing a crucial role in maintaining cell integrity and providing mechanical support. Expression of Cytokeratin 18 is particularly important in epithelial differentiation and tissue specialization, helping to stabilize cell structure under stress. Cytokeratin 18 serves as a biomarker for various types of cancers, including adenocarcinomas and basal cell carcinomas, making Cytokeratin 18 (DC-10) antibody valuable in cancer research and diagnostics. Cytokeratin 18 undergoes significant post-translational modifications, including phosphorylation at specific serine residues, essential for interaction with 14-3-3 proteins. This phosphorylation is critical for proper organization and distribution of keratin filaments within cells, further underscoring Cytokeratin 18′s importance in cellular architecture and function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cytokeratin 18 Antibody (DC-10) has 114 citations in a variety of scientific publications.

Primary antibodies like Anti-Cytokeratin 18 Antibody (DC-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cytokeratin 18 Antibody (DC-10) Specifications

Alternate Product Name: KRT18

Product Clone Name: DC-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Cytokeratin 18

Epitope Species: human

Product Reactivity/Detection: Cytokeratin 18

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 114 citations in various scientific publications

Available Conjugates/Forms for Cytokeratin 18 Antibody (DC-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Cytokeratin 18 antibody is Cytokeratin 18 Antibody (RGE53): sc-32329.