Cytokeratin 14 Antibody (DE-SPK14): sc-58725

Cytokeratin 14 Antibody (DE-SPK14) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 14 in mouse, rat, human, and feline samples through applications such as western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Cytokeratin 14 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and resilience against mechanical stress. Cytokeratin 14 is primarily located in the basal layer of the epidermis, forming heterodimers with other cytokeratins to create intermediate filaments that provide structural support. Cytokeratin 14 helps protect against skin blistering disorders such as epidermolysis bullosa simplex, which arises from mutations in the gene encoding Cytokeratin 14. Anti-Cytokeratin 14 antibody (DE-SPK14) serves as a valuable marker for identifying specific epithelial cell types and aids in diagnosing various skin malignancies, including Bowen′s disease, where expression patterns indicate tumor differentiation. The gene encoding human Cytokeratin 14 is located on chromosome 17q12-21, and understanding Cytokeratin 14 function and expression remains essential for advancing research in dermatology and cancer biology.

The preferred Cytokeratin 14 antibody is Cytokeratin 14 Antibody (LL001): sc-53253.