Cytokeratin 14 Antibody (DE-SPK14): sc-58725

Cytokeratin 14 Antibody (DE-SPK14) is a mouse monoclonal IgG1 antibody that detects Cytokeratin 14 in mouse, rat, human, and feline samples through applications such as western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Cytokeratin 14 is a vital component of the cytoskeletal structure in epithelial cells, playing a crucial role in maintaining cellular integrity and resilience against mechanical stress. Cytokeratin 14 is primarily located in the basal layer of the epidermis, forming heterodimers with other cytokeratins to create intermediate filaments that provide structural support. Cytokeratin 14 helps protect against skin blistering disorders such as epidermolysis bullosa simplex, which arises from mutations in the gene encoding Cytokeratin 14. Anti-Cytokeratin 14 antibody (DE-SPK14) serves as a valuable marker for identifying specific epithelial cell types and aids in diagnosing various skin malignancies, including Bowen′s disease, where expression patterns indicate tumor differentiation. The gene encoding human Cytokeratin 14 is located on chromosome 17q12-21, and understanding Cytokeratin 14 function and expression remains essential for advancing research in dermatology and cancer biology.

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Cytokeratin 14 Antibody (DE-SPK14) References:

1. Amelogenin-cytokeratin 14 interaction in ameloblasts during enamel formation.  |  Ravindranath, RM., et al. 2001. J Biol Chem. 276: 36586-97. PMID: 11425863
2. Cytokeratin 14 immunoreactivity distinguishes oncocytic tumour from its renal mimics: an immunohistochemical study of 63 cases.  |  Chu, PG. and Weiss, LM. 2001. Histopathology. 39: 455-62. PMID: 11737302
3. Loss of cytokeratin 14 expression is related to human papillomavirus type and lesion grade in squamous intraepithelial lesions of the cervix.  |  Southern, SA., et al. 2001. Hum Pathol. 32: 1351-5. PMID: 11774168
4. Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray.  |  Reis-Filho, JS., et al. 2003. Virchows Arch. 443: 122-32. PMID: 12884041
5. Cytokeratin 14 is not a specific marker for renal oncocytomas.  |  Nordling, S. 2006. Am J Surg Pathol. 30: 1337. PMID: 17001169
6. Cytokeratin 14 is expressed in immature cells in rat taste buds.  |  Asano-Miyoshi, M., et al. 2008. J Mol Histol. 39: 193-9. PMID: 17960487
7. Buccal cell cytokeratin 14 identifies mild cognitive impairment and Alzheimer' s disease in the AIBL study of aging.  |  Leifert, WR., et al. 2015. Curr Alzheimer Res. 12: 233-41. PMID: 25731627
8. BRCA-mutated Invasive Breast Carcinomas: Immunohistochemical Analysis of Insulin-like Growth Factor II mRNA-binding Protein (IMP3), Cytokeratin 8/18, and Cytokeratin 14.  |  Mohanty, SK., et al. 2015. Breast J. 21: 596-603. PMID: 26390986
9. Expression of human cytokeratin 14 in normal, premalignant and malignant oral tissue following isolation by plaque differential hybridisation.  |  Marley, JJ., et al. 1994. Eur J Cancer B Oral Oncol. 30B: 305-11. PMID: 7535610
10. Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14.  |  Therkildsen, MH., et al. 1995. APMIS. 103: 558-67. PMID: 7576573

The preferred Cytokeratin 14 antibody is Cytokeratin 14 Antibody (LL001): sc-53253.