cyt19 Antibody (G-5): sc-515112

cyt19 Antibody (G-5) is a mouse monoclonal IgM antibody that detects arsenite methyltransferase (cyt19) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). cyt19 plays a crucial role in the metabolism of inorganic arsenic by catalyzing the transfer of a methyl group from S-adenosylmethionine (AdoMet) to trivalent arsenicals, resulting in the formation of methylated and dimethylated arsenicals. This enzymatic process converts arsenite into methylarsonate, which is subsequently reduced to methylarsonite, a substrate that is further transformed into the significantly less toxic compound dimethylarsinate. cyt19′s localization in the cytoplasm allows for efficient interaction with substrates and facilitates the detoxification of arsenic compounds, thereby playing a protective role against arsenic-induced toxicity. cyt19 is highly expressed in the liver, an organ central to detoxification processes, and inherited variations in this enzyme may influence individual differences in arsenic metabolism and susceptibility to arsenic-related carcinogenesis in humans. anti-cyt19 antibody (G-5) is an essential tool for researchers studying arsenic metabolism and its implications in health and disease.

The preferred cyt19 antibody is cyt19 Antibody (F-9): sc-377436.