cystatin D Antibody (F-3): sc-398553
- cystatin D Antibody (F-3) is a mouse monoclonal IgG2b κ cystatin D antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 22-53 at the N-terminus of cystatin D of human origin
- cystatin D Antibody (F-3) is recommended for detection of precursor and mature cystatin D of human origin by WB, IP, IF and ELISA
- Anti-cystatin D Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for cystatin D Antibody (F-3) for WB applications. This reagent is now offered in a bundle with cystatin D Antibody (F-3) (see ordering information below).
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Cystatin D Antibody (F-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects cystatin D protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cystatin D antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cystatin D, a member of the cystatin superfamily, plays a crucial role as a cysteine protease inhibitor, specifically targeting cathepsins involved in protein degradation and turnover. Such regulation is vital for maintaining cellular homeostasis and preventing excessive proteolysis, which can lead to tissue damage and contribute to various diseases, including cancer and neurodegenerative disorders. Cystatin D is predominantly found in the extracellular space, where this protein helps protect tissues from proteolytic enzymes, playing a significant role in the oral cavity and other bodily fluids. Understanding cystatin D function and importance can provide insights into potential therapeutic applications, particularly in conditions where protease activity is dysregulated.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cystatin D Antibody (F-3) References:
- Involvement of cystatin C in oxidative stress-induced apoptosis of cultured rat CNS neurons. | Nishio, C., et al. 2000. Brain Res. 873: 252-62. PMID: 10930551
- Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping. | Janowski, R., et al. 2001. Nat Struct Biol. 8: 316-20. PMID: 11276250
- Distinct properties of wild-type and the amyloidogenic human cystatin C variant of hereditary cerebral hemorrhage with amyloidosis, Icelandic type. | Calero, M., et al. 2001. J Neurochem. 77: 628-37. PMID: 11299325
- Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. | Manoury, B., et al. 2001. Curr Biol. 11: 447-51. PMID: 11301256
- Cystatin C is an independent predictor of fasting and post-methionine load total homocysteine concentrations among stable renal transplant recipients. | Aras O, ., et al. 2001. Clin Chem. 47: 1263-8. PMID: 11427458
- Cystatins. | Abrahamson, M., et al. 2003. Biochem Soc Symp. 179-99. PMID: 14587292
- Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. | Saitoh, E., et al. 1988. Biol Chem Hoppe Seyler. 369 Suppl: 191-7. PMID: 3202964
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cystatin D Antibody (F-3) | sc-398553 | 200 µg/ml | $322.00 | |||
cystatin D Antibody (F-3): m-IgG2b BP-HRP Bundle | sc-548787 | 200 µg Ab; 10 µg BP | $361.00 | |||
cystatin D Antibody (F-3) AC | sc-398553 AC | 500 µg/ml, 25% agarose | $424.00 | |||
cystatin D Antibody (F-3) HRP | sc-398553 HRP | 200 µg/ml | $322.00 | |||
cystatin D Antibody (F-3) FITC | sc-398553 FITC | 200 µg/ml | $336.00 | |||
cystatin D Antibody (F-3) PE | sc-398553 PE | 200 µg/ml | $349.00 | |||
cystatin D Antibody (F-3) Alexa Fluor® 488 | sc-398553 AF488 | 200 µg/ml | $364.00 | |||
cystatin D Antibody (F-3) Alexa Fluor® 546 | sc-398553 AF546 | 200 µg/ml | $364.00 | |||
cystatin D Antibody (F-3) Alexa Fluor® 594 | sc-398553 AF594 | 200 µg/ml | $364.00 | |||
cystatin D Antibody (F-3) Alexa Fluor® 647 | sc-398553 AF647 | 200 µg/ml | $364.00 | |||
cystatin D Antibody (F-3) Alexa Fluor® 680 | sc-398553 AF680 | 200 µg/ml | $364.00 | |||
cystatin D Antibody (F-3) Alexa Fluor® 790 | sc-398553 AF790 | 200 µg/ml | $364.00 | |||
cystatin D (F-3) Neutralizing Peptide | sc-398553 P | 100 µg/0.5 ml | $69.00 |