CysLT₂ Receptor Antibody (B-7): sc-514181

CysLT2 Receptor Antibody (B-7) is a mouse monoclonal IgM kappa antibody that detects CysLT2 Receptor protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CysLT2 Receptor antibody (B-7) is available as the non-conjugated form. CysLT2 receptor plays a crucial role in mediating the effects of cysteinyl leukotrienes, which are lipid mediators involved in inflammatory responses. CysLT2 receptor is primarily located on the surface of various cell types, including airway smooth muscle cells, macrophages, and certain immune cells such as monocytes and eosinophils. CysLT2 receptor presence in these cells facilitates the binding of cysteinyl leukotrienes, leading to intracellular calcium mobilization and subsequent bronchoconstriction, a key feature in asthma and allergic reactions. CysLT2 receptor interaction with ligands highlights its importance in the pathophysiology of respiratory diseases, making CysLT2 receptor a valuable target for therapeutic intervention. CysLT2 receptor effects can be effectively blocked by specific antagonists, providing a mechanism for developing treatments aimed at alleviating symptoms associated with asthma and other allergic conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CysLT₂ Receptor Antibody (B-7) References:

1. Characterization of the human cysteinyl leukotriene CysLT1 receptor.  |  Lynch, KR., et al. 1999. Nature. 399: 789-93. PMID: 10391245
2. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.  |  Sarau, HM., et al. 1999. Mol Pharmacol. 56: 657-63. PMID: 10462554
3. Characterization of the human cysteinyl leukotriene 2 receptor.  |  Heise, CE., et al. 2000. J Biol Chem. 275: 30531-6. PMID: 10851239
4. Regulation of leukotrienes in the management of asthma: biology and clinical therapy.  |  Leff, AR. 2001. Annu Rev Med. 52: 1-14. PMID: 11160764
5. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing.  |  Maekawa, A., et al. 2001. Proc Natl Acad Sci U S A. 98: 2256-61. PMID: 11226226
6. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.  |  Sjöström, M., et al. 2001. Eur J Biochem. 268: 2578-86. PMID: 11322876
7. Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils.  |  Bandeira-Melo, C., et al. 2002. J Allergy Clin Immunol. 109: 975-9. PMID: 12063527
8. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.  |  Jiang, Y., et al. 2007. Blood. 110: 3263-70. PMID: 17693579
9. Localization and up-regulation of cysteinyl leukotriene-2 receptor in human allergic nasal mucosa.  |  Shirasaki, H., et al. 2013. Allergol Int. 62: 223-8. PMID: 23524649
10. The cysteinyl leukotriene 2 receptor contributes to all-trans retinoic acid-induced differentiation of colon cancer cells.  |  Bengtsson, AM., et al. 2013. BMC Cancer. 13: 336. PMID: 23829413
11. Role of Cysteinyl Leukotrienes in Allergic Rhinitis.  |  Shirasaki, H. and Himi, T. 2016. Adv Otorhinolaryngol. 77: 40-5. PMID: 27115997

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CysLT₂ Receptor Antibody (B-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CysLT₂ Receptor Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CysLT₂ Receptor Antibody (B-7) Specifications

Alternate Product Name: CysLT2 Receptor

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 213-229

Epitope Target: CysLT₂ Receptor

Epitope Species: mouse

Product Reactivity/Detection: CysLT₂ Receptor

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CysLT₂ Receptor Antibody (B-7): P: Blocking Peptide