Cyr61/CCN1 Antibody (H-2): sc-271217
- Cyr61/CCN1 Antibody (H-2) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 345-381 at the C-terminus of Cyr61 of human origin
- recommended for detection of Cyr61 of human origin by WB, IP, IF and ELISA
- See Cyr61/CCN1 (A-10): sc-374129 for Cyr61/CCN1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cyr61/CCN1 Antibody (H-2) for WB applications. These reagents are now offered in bundles with Cyr61/CCN1 Antibody (H-2) (see ordering information below).
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SEE ALSO...
Cyr61 Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects Cyr61 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cyr61 is a secreted heparin-binding protein that plays a crucial role in various biological processes, including angiogenesis and tissue repair. As a member of the CCN protein family, which also includes connective tissue growth factor (CTGF), Cyr61 is vital for cell adhesion and migration, particularly in vascular endothelial cells, where Cyr61 binds to the Integrin αV/β3 receptor. This interaction not only stimulates DNA synthesis but also enhances cell motility, making Cyr61 essential for processes like wound healing and the formation of new blood vessels. Expression of Cyr61 is upregulated during these physiological events, and Cyr61 has been implicated in tumor biology, as Cyr61 is often found in elevated levels in various tumors, serving as a marker for tumor progression. The ability of Cyr61 to influence both normal and pathological processes underscores its significance in research and potential therapeutic applications, making anti-Cyr61 antibody (H-2) an invaluable tool for studying this multifaceted protein.
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Cyr61/CCN1 Antibody (H-2) References:
- Cyr61/CTGF/Nov family proteins in gastric carcinogenesis. | Cheng, TY., et al. 2014. World J Gastroenterol. 20: 1694-700. PMID: 24587648
- Cyr61/CCN1 targets for chemosensitization in pancreatic cancer. | Banerjee, S., et al. 2019. Oncotarget. 10: 3579-3580. PMID: 31217893
- The Roles of CCN1/CYR61 in Pulmonary Diseases. | Zhu, Y., et al. 2020. Int J Mol Sci. 21: PMID: 33105556
- Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment. | Yin, S., et al. 2022. J Hematol Oncol. 15: 32. PMID: 35313929
- Increased CYR61 expression activates CCND1/c-Myc pathway to promote nasal epithelial cells proliferation in chronic rhinosinusitis with nasal polyps. | Luo, C., et al. 2023. Clin Immunol. 247: 109235. PMID: 36681101
- Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61 m6A. | Song, YP., et al. 2023. Environ Health Perspect. 131: 97004. PMID: 37682722
- Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis. | Mooring, M., et al. 2023. Sci Transl Med. 15: eade3157. PMID: 37756381
- Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma. | Zhang, C., et al. 2024. J Biol Chem. 300: 107208. PMID: 38521502
- Cyr61 delivery promotes angiogenesis during bone fracture repair. | Lang, A., et al. 2024. bioRxiv.. PMID: 38617208
- CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway. | Hu, K., et al. 2024. Int J Biol Sci. 20: 3140-3155. PMID: 38904029
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyr61/CCN1 Antibody (H-2) | sc-271217 | 200 µg/ml | $322.00 | |||
Cyr61/CCN1 Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-537590 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cyr61/CCN1 Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-534898 | 200 µg Ab; 40 µg BP | $361.00 | |||
Cyr61/CCN1 Antibody (H-2): m-IgG1 BP-HRP Bundle | sc-545248 | 200 µg Ab; 20 µg BP | $361.00 | |||
Cyr61/CCN1 (H-2) Neutralizing Peptide | sc-271217 P | 100 µg/0.5 ml | $69.00 |