CyPA Antibody (6-YD13): sc-134310

CyPA Antibody (6-YD13) is a mouse monoclonal IgG2a kappa light chain antibody that detects CyPA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CyPA antibody (6-YD13) is available as a non-conjugated format and plays a critical role in various biological processes, particularly in T cell differentiation and proliferation, which are essential for a robust immune response. CyPA protein, consisting of 165 amino acids, is encoded by a single unique gene that is conserved across species from yeast to humans. CyPA′s intracellular location allows interaction with various cellular components, including the immunosuppressant cyclosporin A (CsA), forming a trimolecular complex alongside calcineurin to inhibit calcineurin phosphatase activity. This inhibition is crucial for regulating T cell activation, making CyPA a key player in immune responses. Additionally, CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1), where CyPA interacts directly with the capsid domain of the viral Gag polyprotein, facilitating efficient viral replication. Understanding CyPA′s interactions and functions highlights CyPA′s importance in immunology and potential as a therapeutic target in various diseases, including viral infections and autoimmune disorders.

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CyPA Antibody (6-YD13) References:

1. Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain.  |  Endrich, MM., et al. 1999. J Biol Chem. 274: 5326-32. PMID: 10026140
2. Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.  |  Wang, P., et al. 2001. EMBO Rep. 2: 511-8. PMID: 11415984
3. Effects of altered cyclophilin A expression on growth and differentiation of human and mouse neuronal cells.  |  Nahreini, P., et al. 2001. Cell Mol Neurobiol. 21: 65-79. PMID: 11440199
4. s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.  |  Arber, S., et al. 1992. J Cell Biol. 116: 113-25. PMID: 1530944
5. An endoplasmic reticulum-specific cyclophilin.  |  Hasel, KW., et al. 1991. Mol Cell Biol. 11: 3484-91. PMID: 1710767
6. In situ detection of cyclosporin A: evidence for nuclear localization of cyclosporine and cyclophilins.  |  Le Hir, M., et al. 1995. Lab Invest. 73: 727-33. PMID: 7474947
7. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex.  |  Pflügl, G., et al. 1993. Nature. 361: 91-4. PMID: 8421501
8. Evidence that human milk isolated cyclophilin B corresponds to a truncated form.  |  Mariller, C., et al. 1996. Biochim Biophys Acta. 1293: 31-8. PMID: 8652625
9. Involvement of the N-terminal part of cyclophilin B in the interaction with specific Jurkat T-cell binding sites.  |  Mariller, C., et al. 1996. Biochem J. 317 (Pt 2): 571-6. PMID: 8713087
10. Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.  |  Vajdos, FF., et al. 1997. Protein Sci. 6: 2297-307. PMID: 9385632

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CyPA Antibody (6-YD13) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-CyPA Antibody (6-YD13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CyPA Antibody (6-YD13) Specifications

Alternate Product Name: Peptidylprolyl Isomerase A

Product Clone Name: 6-YD13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-166

Epitope Target: CyPA

Epitope Species: human

Product Reactivity/Detection: CyPA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for CyPA Antibody (6-YD13): N/A