CYP4A1 Antibody (clo1): sc-53248

CYP4A1 Antibody (clo1) is a mouse monoclonal IgG1 antibody that detects CYP4A1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). CYP4A1 (clo1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CYP4A1 plays a crucial role in fatty acid metabolism and bioactive lipid biosynthesis, which are essential for maintaining cellular homeostasis and regulating inflammatory responses. Specifically, CYP4A1 is involved in omega-hydroxylation of fatty acids, leading to hydroxyeicosatetraenoic acids (HETEs) production, which are important signaling molecules in various physiological processes, including blood pressure regulation and immune response modulation. CYP4A1 ability to metabolize both endogenous substrates and exogenous compounds, such as drugs and toxins, highlights CYP4A1′s significance in pharmacology and toxicology, making anti-CYP4A1 antibody (clo1) an invaluable tool for researchers studying drug metabolism and fatty acid derivative roles.

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CYP4A1 Antibody (clo1) References:

1. CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR.  |  Wang, MH., et al. 2001. Am J Physiol Regul Integr Comp Physiol. 280: R255-61. PMID: 11124159
2. The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands.  |  Cowart, LA., et al. 2002. J Biol Chem. 277: 35105-12. PMID: 12124379
3. Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels.  |  Jiang, M., et al. 2004. Circ Res. 94: 167-74. PMID: 14670847
4. Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli.  |  Zhang, F., et al. 2004. Am J Physiol Heart Circ Physiol. 287: H1089-95. PMID: 15130884
5. Major role of soybean oil in preventing decrease in CYP4A1 mRNA content relative to PPARalpha mRNA down-regulation in infant rats.  |  Nishimura, M., et al. 2005. Biol Pharm Bull. 28: 1517-20. PMID: 16079505
6. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.  |  Kimura, S., et al. 1989. DNA. 8: 503-16. PMID: 2766932
7. [Effects of perfluorooctanoic acid on oxidative stress and PPARα and its related CYP4A1 gene expression in rat liver].  |  Wang, L., et al. 2017. Wei Sheng Yan Jiu. 46: 802-806. PMID: 29903312
8. Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription.  |  Aldridge, TC., et al. 1995. Biochem J. 306 (Pt 2): 473-9. PMID: 7887901
9. The cytochrome P450 4 (CYP4) family.  |  Simpson, AE. 1997. Gen Pharmacol. 28: 351-9. PMID: 9068972
10. Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6, and dexamethasone in cultured fetal rat hepatocytes.  |  Parmentier, JH., et al. 1997. Biochem Pharmacol. 54: 889-98. PMID: 9354589
11. Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole.  |  Dierks, EA., et al. 1998. Biochemistry. 37: 1839-47. PMID: 9485309
12. CYP4A1 gene transfection studies and the peroxisome proliferator-activated receptor: development of a high-throughput assay to detect peroxisome proliferators.  |  Giddings, SJ., et al. 1997. Eur J Drug Metab Pharmacokinet. 22: 315-9. PMID: 9512927

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CYP4A1 Antibody (clo1) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-CYP4A1 Antibody (clo1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CYP4A1 Antibody (clo1) Specifications

Alternate Product Name: CYP4A1

Product Clone Name: clo1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: liver cytochrome P450 2C11 and 4A1

Epitope Species: rat

Product Reactivity/Detection: CYP4A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for CYP4A1 Antibody (clo1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin