CYP2B1/2B2 Antibody (b/e3): sc-53242

CYP2B10 Antibody (b/e3) is a mouse monoclonal IgG1 antibody that detects CYP2B10 in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). CYP2B10 is a crucial member of the cytochrome P450 (CYP) superfamily, which plays a significant role in the metabolism of various endogenous and exogenous compounds, including drugs and fatty acids. Anti-CYP2B10 antibody (b/e3) targets this protein primarily in the liver, where CYP2B10 is involved in the oxidative metabolism of a wide range of substances, thereby influencing drug clearance and the bioactivation of prodrugs. The liver′s unique environment allows CYP2B10 to interact with various substrates, making CYP2B10 essential for maintaining metabolic homeostasis and detoxifying harmful compounds. Additionally, CYP2B10 undergoes post-translational modifications, such as phosphorylation, which can affect enzymatic activity and stability, further underscoring CYP2B10′s importance in pharmacokinetics and toxicology. CYP2B10 monoclonal antibody (b/e3) enables researchers to gain valuable insights into the functional dynamics of this enzyme and its implications in drug metabolism and disease states.

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CYP2B1/2B2 Antibody (b/e3) References:

1. Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: the dalcetrapib experience.  |  Hoflack, JC., et al. 2012. Toxicol Appl Pharmacol. 259: 355-65. PMID: 22293087
2. Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.  |  Ashino, T., et al. 2014. Redox Biol. 2: 284-8. PMID: 24494203
3. The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.  |  Ohno, M., et al. 2014. PLoS One. 9: e115663. PMID: 25542016
4. Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.  |  Koga, T., et al. 2016. J Biol Chem. 291: 25255-25263. PMID: 27765815
5. Dietary Squalene Induces Cytochromes Cyp2b10 and Cyp2c55 Independently of Sex, Dose, and Diet in Several Mouse Models.  |  Gabás-Rivera, C., et al. 2020. Mol Nutr Food Res. 64: e2000354. PMID: 32918392
6. mmu-miR-199a-5p regulates CYP2B10 through repression of E4BP4 in mouse AML-12 hepatocytes.  |  Ren, S., et al. 2021. Xenobiotica. 51: 1101-1109. PMID: 34382487
7. Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver.  |  Chen, M., et al. 2021. Front Pharmacol. 12: 764124. PMID: 34887762
8. Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway.  |  Wu, J., et al. 2022. Tissue Cell. 78: 101891. PMID: 35985247
9. Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury.  |  Mackowiak, B., et al. 2022. Alcohol Clin Exp Res. 46: 2163-2176. PMID: 36224745
10. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes.  |  Honkakoski, P. and Negishi, M. 1998. Biochem J. 330 (Pt 2): 889-95. PMID: 9480906

The preferred CYP2B1/2B2 antibody is CYP2B1/2B2 Antibody (9.14): sc-73546.