cylindromatosis 1 Antibody (H-6): sc-137139

Cylindromatosis 1 Antibody (H-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects cylindromatosis 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cylindromatosis 1 antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cylindromatosis 1 protein, encoded by the human CYLD gene located on chromosome 16q12.1, plays a crucial role in cellular signaling pathways by acting as a deubiquitinating enzyme, specifically targeting lysine 63-linked ubiquitin chains. This function is vital for regulating protein degradation and maintaining cellular homeostasis, as cylindromatosis 1 influences processes such as inflammation and tumor suppression. Mutations in the CYLD gene can lead to familial cylindromatosis, a condition characterized by the development of multiple benign skin tumors known as cylindromas, which can become infected and lead to significant discomfort and disfigurement. Cylindromatosis 1 expression is observed in various tissues, including brain, gonads, skeletal muscle, spleen, liver, heart, lung, and leukocytes, highlighting cylindromatosis 1′s importance in diverse biological functions. Additionally, somatic mutations in the CYLD gene have been implicated in the oncogenesis of tumors exhibiting cylindromatous features, underscoring cylindromatosis 1′s relevance in cancer research and therapeutic development.

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cylindromatosis 1 Antibody (H-6) References:

1. Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure.  |  Liu, Y., et al. 1999. Toxicol Sci. 50: 221-7. PMID: 10478858
2. Apoptosis by Cd2+ or CdMT in proximal tubule cells: different uptake routes and permissive role of endo/lysosomal CdMT uptake.  |  Erfurt, C., et al. 2003. Am J Physiol Cell Physiol. 285: C1367-76. PMID: 12890648
3. Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.  |  Ang, RL., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34887354
4. CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.  |  Wang, L., et al. 2022. Cancer Lett. 532: 215586. PMID: 35131382
5. CYLD expression in endometrial carcinoma and correlation with clinicohistopathological parameters.  |  Papadatou, V., et al. 2022. Taiwan J Obstet Gynecol. 61: 596-600. PMID: 35779906
6. Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency.  |  Bekas, N., et al. 2023. Cancers (Basel). 15: PMID: 37894364
7. CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1.  |  Jiang, G., et al. 2024. J Orthop Surg Res. 19: 212. PMID: 38561786
8. Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation.  |  Schramm, E., et al. 2024. J Mol Med (Berl). 102: 1381-1393. PMID: 39302418
9. CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments.  |  Yang, S., et al. 2024. Adv Sci (Weinh). 11: e2404067. PMID: 39373352
10. Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats.  |  Liu, J., et al. 1998. Toxicol Appl Pharmacol. 153: 48-58. PMID: 9875299

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cylindromatosis 1 Antibody (H-6) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-cylindromatosis 1 Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cylindromatosis 1 Antibody (H-6) Specifications

Alternate Product Name: CYLD

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 537-956

Epitope Target: cylindromatosis 1

Epitope Species: human

Product Reactivity/Detection: cylindromatosis 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for cylindromatosis 1 Antibody (H-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred cylindromatosis 1 antibody is cylindromatosis 1 Antibody (E-10): sc-74435.