cyclin T1 Antibody (E-6): sc-271576

Cyclin T1 Antibody (E-6) is a mouse monoclonal IgG2b antibody that detects cyclin T1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cyclin T1 plays a crucial role in the regulation of transcription elongation by forming a complex with cyclin-dependent kinase 9 (Cdk9), which is essential for the phosphorylation of the C-terminal domain of RNA polymerase II. This phosphorylation is vital for the transition of RNA polymerase II from transcription initiation to elongation, thereby facilitating the production of mRNA. The interaction between cyclin T1 and the HIV-1 Tat protein is particularly significant, as cyclin T1 enhances Tat′s binding affinity to the viral TAR RNA, allowing for the recruitment of the cyclin T1/Cdk9 complex to RNA polymerase II. This mechanism underscores cyclin T1′s importance in both cellular transcription processes and viral pathogenesis, making cyclin T1 a key target for research in gene expression and HIV biology. Anti-cyclin T1 antibody (E-6) serves as an invaluable tool for studying these complex interactions and their implications in various biological contexts.

The preferred cyclin T1 antibody is cyclin T1 Antibody (E-3): sc-271348.