cyclin E Antibody (B-7): sc-48420
- cyclin E Antibody (B-7) is a mouse monoclonal IgG2a κ, cited in 12 publications, provided at 200 µg/ml
- raised against amino acids 1-145 of cyclin E of human origin
- recommended for detection of cyclin E of human origin by WB, IP, IF and IHC(P)
- See cyclin E (E-4): sc-377100 for cyclin E antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for cyclin E Antibody (B-7) for WB and IHC(P) applications. These reagents are now offered in bundles with cyclin E Antibody (B-7) (see ordering information below).
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Cyclin E Antibody (B-7) is a mouse monoclonal IgG2a antibody that detects cyclin E in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cyclin E plays a pivotal role in the regulation of the cell cycle, particularly during the transition from the G1 phase to the S phase, where cyclin E is crucial for the initiation of DNA replication. Cyclin E is primarily located in the nucleus, where cyclin E forms a complex with the transcription factor E2F, facilitating the expression of genes necessary for S phase entry. The cyclin E/E2F complex is essential for the proper progression of the cell cycle, as cyclin E ensures that cells are adequately prepared for DNA synthesis. Dysregulation of cyclin E has been implicated in various cancers, making cyclin E a significant focus of research in understanding tumorigenesis and potential therapeutic interventions. Anti-cyclin E antibody (B-7) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin E Antibody (B-7) References:
- Targeting low molecular weight cyclin E (LMW-E) in breast cancer. | Nanos-Webb, A., et al. 2012. Breast Cancer Res Treat. 132: 575-88. PMID: 21695458
- Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. | Odajima, J., et al. 2011. Dev Cell. 21: 655-68. PMID: 21944720
- Meta-analysis for cyclin E in lung cancer survival. | Huang, LN., et al. 2012. Clin Chim Acta. 413: 663-8. PMID: 22244930
- Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis. | Pok, S., et al. 2013. J Gastroenterol Hepatol. 28: 1545-54. PMID: 23574010
- Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. | Liu, NA., et al. 2015. J Clin Endocrinol Metab. 100: 2557-64. PMID: 25942479
- Cyclin E Expression Correlates with Cancer-specific Survival in Endometrial Endometrioid Adenocarcinoma. | Santala, S., et al. 2015. Anticancer Res. 35: 3393-7. PMID: 26026100
- Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics. | Choudhary, GS., et al. 2015. Oncotarget. 6: 16912-25. PMID: 26219338
- Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer. | Hunt, KK., et al. 2017. Clin Cancer Res. 23: 2991-3002. PMID: 27881578
- Expression of Cyclin E/Cdk2/p27Kip1 in Growth Hormone Adenomas. | Dong, W., et al. 2019. World Neurosurg. 121: e45-e53. PMID: 30196178
- The role of cyclin E in the regulation of entry into S phase. | Sauer, K. and Lehner, CF. 1995. Prog Cell Cycle Res. 1: 125-39. PMID: 9552358
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin E Antibody (B-7) | sc-48420 | 200 µg/ml | $322.00 | |||
cyclin E Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-538940 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin E Antibody (B-7): m-IgG2a BP-HRP Bundle | sc-546649 | 200 µg Ab; 10 µg BP | $361.00 |