cyclin E Antibody (B-7): sc-48420

Cyclin E Antibody (B-7) is a mouse monoclonal IgG2a antibody that detects cyclin E in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Cyclin E plays a pivotal role in the regulation of the cell cycle, particularly during the transition from the G1 phase to the S phase, where cyclin E is crucial for the initiation of DNA replication. Cyclin E is primarily located in the nucleus, where cyclin E forms a complex with the transcription factor E2F, facilitating the expression of genes necessary for S phase entry. The cyclin E/E2F complex is essential for the proper progression of the cell cycle, as cyclin E ensures that cells are adequately prepared for DNA synthesis. Dysregulation of cyclin E has been implicated in various cancers, making cyclin E a significant focus of research in understanding tumorigenesis and potential therapeutic interventions. Anti-cyclin E antibody (B-7) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation.

The preferred cyclin E antibody is cyclin E Antibody (HE12): sc-247.