cyclin D3 Antibody (18B6-10): sc-453
- cyclin D3 Antibody (18B6-10) is a rat monoclonal IgG2a, cited in 39 publications, provided at 200 µg/ml
- raised against recombinant cyclin D3 protein of mouse origin
- Anti-cyclin D3 Antibody (18B6-10) is recommended for detection of cyclin D3 p34 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-cyclin D3 Antibody (18B6-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for cyclin D3 Antibody (18B6-10). This work is in progress.
QUICK LINKS
Cyclin D3 Antibody (18B6-10) is a rat monoclonal IgG2a antibody that detects cyclin D3 p34 in mouse, rat, and human samples through applications such as western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry, and enzyme-linked immunosorbent assay. Cyclin D3 (18B6-10) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Cyclin D3 plays a pivotal role in cell cycle regulation, particularly during the G1 to S phase transition, where cyclin D3 is essential for the progression of cells from a quiescent state to active division. This transition is crucial for proper cellular proliferation and growth, as cyclin D3 ensures that cells only replicate their DNA and divide when they are ready, thus preventing uncontrolled cell growth that can lead to tumorigenesis. The cyclin D family, including cyclin D3, is known to interact with cyclin-dependent kinases (CDKs) to phosphorylate the retinoblastoma protein, which in turn activates E2F transcription factors that drive the expression of genes necessary for DNA synthesis. The dysregulation of cyclin D3 and its associated pathways has been implicated in various cancers, highlighting cyclin D3′s importance as a target for therapeutic intervention and as a biomarker for disease progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin D3 Antibody (18B6-10) | sc-453 | 200 µg/ml | $322.00 | |||
cyclin D3 Antibody (18B6-10) AC | sc-453 AC | 500 µg/ml, 25% agarose | $424.00 | |||
cyclin D3 Antibody (18B6-10) HRP | sc-453 HRP | 200 µg/ml | $322.00 | |||
cyclin D3 Antibody (18B6-10) FITC | sc-453 FITC | 200 µg/ml | $336.00 | |||
cyclin D3 Antibody (18B6-10) PE | sc-453 PE | 200 µg/ml | $349.00 | |||
cyclin D3 Antibody (18B6-10) Alexa Fluor® 488 | sc-453 AF488 | 200 µg/ml | $364.00 | |||
cyclin D3 Antibody (18B6-10) Alexa Fluor® 546 | sc-453 AF546 | 200 µg/ml | $364.00 | |||
cyclin D3 Antibody (18B6-10) Alexa Fluor® 594 | sc-453 AF594 | 200 µg/ml | $364.00 | |||
cyclin D3 Antibody (18B6-10) Alexa Fluor® 647 | sc-453 AF647 | 200 µg/ml | $364.00 | |||
cyclin D3 Antibody (18B6-10) Alexa Fluor® 680 | sc-453 AF680 | 200 µg/ml | $364.00 | |||
cyclin D3 Antibody (18B6-10) Alexa Fluor® 790 | sc-453 AF790 | 200 µg/ml | $364.00 |