CCNB1/cyclin B1 Antibody (V143.1): sc-53235
- CCNB1/cyclin B1 Antibody (V143.1) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against hamster cyclin B1
- recommended for detection of cyclin B1 of mouse, rat and human origin by WB and IP
- See CCNB1/cyclin B1 (GNS1): sc-245 for CCNB1/cyclin B1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CCNB1/cyclin B1 Antibody (V143.1) for WB applications. This reagent is now offered in a bundle with CCNB1/cyclin B1 Antibody (V143.1) (see ordering information below).
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Cyclin B1 Antibody (V143.1) is a mouse monoclonal IgG1 antibody raised against hamster cyclin B1, suitable for applications such as western blotting (WB) and immunoprecipitation (IP) in mouse, rat, and human samples. Cyclin B1, also known as CCNB1, is a regulatory protein essential for controlling the G2/M transition during the cell cycle by forming a complex with cyclin-dependent kinase 1 (CDK1), also referred to as CDC2. This complex, known as the maturation-promoting factor (MPF), initiates mitosis by phosphorylating target substrates. The structure of cyclin B1 includes a conserved cyclin box domain crucial for binding to CDK1 and regulating its kinase activity. Additionally, cyclin B1 contains regulatory regions that control localization and degradation, ensuring precise cell cycle progression. Structural integrity of cyclin B1 is important because alterations can disrupt interaction with CDK1, leading to cell cycle dysregulation. Dysregulation of cyclin B1 has been associated with uncontrolled cell proliferation and various cancers, highlighting the importance of structural study. By utilizing cyclin B1 monoclonal antibody (V143.1), researchers can investigate the expression, structure, and function of cyclin B1, contributing to a better understanding of cell cycle regulation and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCNB1/cyclin B1 Antibody (V143.1) | sc-53235 | 200 µg/ml | $322.00 | |||
CCNB1/cyclin B1 Antibody (V143.1): m-IgG Fc BP-HRP Bundle | sc-538981 | 200 µg Ab; 10 µg BP | $361.00 |