CCNB1/cyclin B1 Antibody (G-11): sc-166757
- CCNB1/cyclin B1 Antibody (G-11) is a mouse monoclonal IgG2a κ, cited in 23 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 414-433 at the C-terminus of cyclin B1 of human origin
- recommended for detection of cyclin B1 of human origin by WB, IP, IF, IHC(P) and ELISA
- See CCNB1/cyclin B1 (GNS1): sc-245 for CCNB1/cyclin B1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CCNB1/cyclin B1 Antibody (G-11) for WB and IHC(P) applications. These reagents are now offered in bundles with CCNB1/cyclin B1 Antibody (G-11) (see ordering information below).
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cyclin B1 Antibody (G-11) is a mouse monoclonal IgG2a kappa light chain antibody that recognizes an epitope mapping between amino acids 414-433 at the C-terminus of human cyclin B1. cyclin B1, also known as CCNB1, is a key regulatory protein involved in controlling the progression from the G2 phase to mitosis during the cell cycle. cyclin B1 forms a complex with cyclin-dependent kinase 1 (Cdk1), activating the maturation-promoting factor (MPF) essential for initiating mitosis. cyclin B1 accumulates in the cytoplasm during interphase and translocates to the nucleus at the onset of mitosis, facilitating chromatin condensation and nuclear envelope breakdown; this spatial regulation is crucial for proper cell division. Dysregulation of cyclin B1 levels or localization can lead to uncontrolled cell proliferation, contributing to the development of various cancers. anti-cyclin B1 antibody (G-11) is reactive with human cyclin B1 and is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). cyclin B1 (G-11) antibody aids in studying cell cycle dynamics and the mechanisms underlying mitotic entry and progression. Recognizing cyclin B1 interactions with regulatory partners like Cdc2 (Cdk1) and phosphatases such as Cdc25A and Cdc25B, anti-cyclin B1 antibody (G-11) supports research into cell proliferation disorders and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCNB1/cyclin B1 Antibody (G-11) | sc-166757 | 200 µg/ml | $322.00 | |||
CCNB1/cyclin B1 Antibody (G-11): m-IgG Fc BP-HRP Bundle | sc-540155 | 200 µg Ab; 10 µg BP | $361.00 | |||
CCNB1/cyclin B1 Antibody (G-11): m-IgG2a BP-HRP Bundle | sc-546863 | 200 µg Ab; 10 µg BP | $361.00 | |||
CCNB1/cyclin B1 (G-11) Neutralizing Peptide | sc-166757 P | 100 µg/0.5 ml | $69.00 |