CCNB1/cyclin B1 Antibody (0.N.238): sc-70898
- CCNB1/cyclin B1 Antibody (0.N.238) is a mouse monoclonal IgG1 κ, cited in 17 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to human cyclin B1
- recommended for detection of cyclin B1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and KA
- See CCNB1/cyclin B1 (GNS1): sc-245 for CCNB1/cyclin B1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for CCNB1/cyclin B1 Antibody (0.N.238) for WB and IHC(P) applications. This reagent is now offered in a bundle with CCNB1/cyclin B1 Antibody (0.N.238) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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cyclin B1 Antibody (0.N.238) is a mouse monoclonal IgG1 kappa light chain antibody raised against a recombinant protein corresponding to human cyclin B1, also known as CCNB1 or G2/mitotic-specific cyclin-B1. Anti-cyclin B1 antibody (0.N.238) reacts with mouse, rat, and human species and is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Cyclin B1 is a key regulatory protein that controls the progression of cells from the G2 phase to mitosis by forming a complex with cyclin-dependent kinase 1 (CDK1), also known as CDC2, to create the maturation-promoting factor (MPF). Cyclin B1 function is vital for mitosis initiation, activating CDK1 to phosphorylate various substrates necessary for chromosome condensation, nuclear envelope breakdown, and spindle formation. Cyclin B1 levels are tightly regulated during the cell cycle, accumulating during the S and G2 phases and undergoing rapid degradation after mitosis, ensuring proper cell cycle progression. Dysregulation of cyclin B1 can lead to uncontrolled cell proliferation and is associated with various cancers, highlighting cyclin B1′s importance in maintaining normal cellular functions. Studying cyclin B1 provides insights into cell division mechanisms and offers potential targets for cancer therapy. Anti-cyclin B1 antibody (0.N.238) enables researchers to effectively investigate cyclin B1 expression, localization, and function in different biological contexts, contributing to advancements in cell biology and oncology research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCNB1/cyclin B1 Antibody (0.N.238) | sc-70898 | 200 µg/ml | $322.00 | |||
CCNB1/cyclin B1 Antibody (0.N.238): m-IgGκ BP-HRP Bundle | sc-521092 | 200 µg Ab, 40 µg BP | $361.00 |