cyclin A1 Antibody (XLA1-3): sc-56301
- cyclin A1 Antibody (XLA1-3) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against full length cyclin A1 of Xenopus laevis origin
- recommended for detection of cyclin A1 of Xenopus laevis origin by WB, IP and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for cyclin A1 Antibody (XLA1-3) for WB applications. This reagent is now offered in a bundle with cyclin A1 Antibody (XLA1-3) (see ordering information below).
QUICK LINKS
Cyclin A1 Antibody (XLA1-3) is a mouse monoclonal IgG1 antibody that detects cyclin A1 in Xenopus laevis through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Cyclin A1 plays a pivotal role in the regulation of the cell cycle, particularly in germ cells, where cyclin A1 is most abundantly expressed. Cyclin A1 is crucial for the proper progression of meiosis, as cyclin A1 helps to coordinate the activities of cyclin-dependent kinases, which are essential for cell division. Anti-cyclin A1 antibody (XLA1-3) interaction with cyclin-dependent kinase-2 (Cdk2) and other regulatory proteins ensures that the cell cycle transitions occur smoothly, preventing errors that could lead to developmental abnormalities or tumorigenesis. Additionally, cyclin A1′s high sequence homology to Xenopus cyclin A1 suggests evolutionary conservation of its function, highlighting cyclin A1′s importance in cellular processes. Cyclin A1 (XLA1-3) monoclonal antibody is an invaluable tool for researchers studying cell cycle dynamics and the specific roles of cyclins in germ cell development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin A1 Antibody (XLA1-3) References:
- Cyclin A1 expression in leukemia and normal hematopoietic cells. | Yang, R., et al. 1999. Blood. 93: 2067-74. PMID: 10068680
- Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma. | Liu, Y., et al. 2013. Mol Cell Biochem. 384: 221-7. PMID: 24002705
- Cyclin A1 is expressed in mouse ovary. | Wei, H., et al. 2014. Int J Med Sci. 11: 754-7. PMID: 24904232
- Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection. | Munari, E., et al. 2015. Histopathology. 66: 262-9. PMID: 25039670
- Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches. | Miftakhova, R., et al. 2015. Cell Cycle. 14: 1948-60. PMID: 25785996
- WT1 regulates cyclin A1 expression in K562 cells. | Pandey, S., et al. 2019. Oncol Rep. 42: 2016-2028. PMID: 31436300
- SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. | Zhou, Y., et al. 2021. Acta Pharm Sin B. 11: 89-99. PMID: 33532182
- TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA. | Chen, XZ., et al. 2023. Cell Death Differ. 30: 1786-1798. PMID: 37286744
- Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts. | Du, X., et al. 2024. BMC Musculoskelet Disord. 25: 206. PMID: 38454404
- Cyclin A1 is required for meiosis in the male mouse. | Liu, D., et al. 1998. Nat Genet. 20: 377-80. PMID: 9843212
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin A1 Antibody (XLA1-3) | sc-56301 | 200 µg/ml | $322.00 | |||
cyclin A1 Antibody (XLA1-3): m-IgG Fc BP-HRP Bundle | sc-539033 | 200 µg Ab; 10 µg BP | $361.00 |