cyclin A Antibody (H-3): sc-271645

Cyclin A Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects cyclin A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cyclin A antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cyclin A plays a pivotal role in regulating the eukaryotic cell cycle, particularly during S phase, where cyclin A is crucial for proper DNA replication progression. Cyclin A is primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinase-2 (Cdk2) to form active complexes that drive cell cycle transitions. Precise cyclin A localization ensures timely and orderly cell cycle progression, preventing errors that could lead to genomic instability or uncontrolled cell proliferation. Cyclin A has been implicated in various cellular processes, including cell transformation, and interacts with key regulatory proteins such as E1A, transcription factors DRTF1 and E2F, and retinoblastoma protein, p110. A second form, cyclin A1, is predominantly expressed in germ cells and associates with Cdk2, p39, and Cdc2 p34, highlighting diverse cyclin roles in cellular regulation and development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cyclin A Antibody (H-3) has 33 citations in a variety of scientific publications.

Primary antibodies like Anti-cyclin A Antibody (H-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cyclin A Antibody (H-3) Specifications

Alternate Product Name: cyclin A

Product Clone Name: H-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-432

Epitope Target: cyclin A

Epitope Species: human

Product Reactivity/Detection: cyclin A and cyclin A1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 33 citations in various scientific publications

Available Conjugates/Forms for cyclin A Antibody (H-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred cyclin A antibody is cyclin A Antibody (BF683): sc-239.