CUEDC1 Antibody (G-4): sc-393828
- CUEDC1 Antibody (G-4) is a mouse monoclonal IgG1 κ CUEDC1 antibody provided at 200 µg/ml
- raised against amino acids 232-315 mapping within an internal region of CUEDC1 of human origin
- CUEDC1 Antibody (G-4) is recommended for detection of CUEDC1 of human origin by WB, IP, IF and ELISA
- Anti-CUEDC1 Antibody (G-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CUEDC1 Antibody (G-4) for WB applications. These reagents are now offered in bundles with CUEDC1 Antibody (G-4) (see ordering information below).
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CUEDC1 Antibody (G-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects CUEDC1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CUEDC1 (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. CUEDC1 consists of 386 amino acids and features a CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain, playing a crucial role in protein trafficking and degradation pathways within the cell. This CUE domain, approximately 40 amino acids in length, is essential for binding monoubiquitin, which is vital for the ubiquitination process that regulates protein stability and function. Notably, defects in CUEDC1 have been linked to early-stage cervical cancer, highlighting CUEDC1′s potential as a tumor marker and underscoring the importance of understanding CUEDC1′s function in cellular processes. Additionally, two isoforms of CUEDC1 arise from alternative splicing, which may contribute to CUEDC1′s functional diversity and regulatory mechanisms in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CUEDC1 Antibody (G-4) References:
- Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. | Ponting, CP. 2000. Biochem J. 351 Pt 2: 527-35. PMID: 11023840
- A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. | Shih, SC., et al. 2003. EMBO J. 22: 1273-81. PMID: 12628920
- Mechanism of ubiquitin recognition by the CUE domain of Vps9p. | Prag, G., et al. 2003. Cell. 113: 609-20. PMID: 12787502
- Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. | Kang, RS., et al. 2003. Cell. 113: 621-30. PMID: 12787503
- Functional proteomics mapping of a human signaling pathway. | Colland, F., et al. 2004. Genome Res. 14: 1324-32. PMID: 15231748
- Gene expression in early stage cervical cancer. | Biewenga, P., et al. 2008. Gynecol Oncol. 108: 520-6. PMID: 18191186
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CUEDC1 Antibody (G-4) | sc-393828 | 200 µg/ml | $322.00 | |||
CUEDC1 Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-530592 | 200 µg Ab; 10 µg BP | $361.00 | |||
CUEDC1 Antibody (G-4): m-IgGκ BP-HRP Bundle | sc-524106 | 200 µg Ab, 40 µg BP | $361.00 | |||
CUEDC1 Antibody (G-4): m-IgG1 BP-HRP Bundle | sc-544151 | 200 µg Ab; 20 µg BP | $361.00 | |||
CUEDC1 Antibody (G-4) AC | sc-393828 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CUEDC1 Antibody (G-4) HRP | sc-393828 HRP | 200 µg/ml | $322.00 | |||
CUEDC1 Antibody (G-4) FITC | sc-393828 FITC | 200 µg/ml | $336.00 | |||
CUEDC1 Antibody (G-4) PE | sc-393828 PE | 200 µg/ml | $349.00 | |||
CUEDC1 Antibody (G-4) Alexa Fluor® 488 | sc-393828 AF488 | 200 µg/ml | $364.00 | |||
CUEDC1 Antibody (G-4) Alexa Fluor® 546 | sc-393828 AF546 | 200 µg/ml | $364.00 | |||
CUEDC1 Antibody (G-4) Alexa Fluor® 594 | sc-393828 AF594 | 200 µg/ml | $364.00 | |||
CUEDC1 Antibody (G-4) Alexa Fluor® 647 | sc-393828 AF647 | 200 µg/ml | $364.00 | |||
CUEDC1 Antibody (G-4) Alexa Fluor® 680 | sc-393828 AF680 | 200 µg/ml | $364.00 | |||
CUEDC1 Antibody (G-4) Alexa Fluor® 790 | sc-393828 AF790 | 200 µg/ml | $364.00 |